DTX2

Gene Symbol DTX2
Entrez Gene 113878
Alt Symbol RNF58
Species Human
Gene Type protein-coding
Description deltex 2, E3 ubiquitin ligase
Other Description deltex homolog 2|deltex2|hDTX2|probable E3 ubiquitin-protein ligase DTX2|protein deltex-2|ring finger protein 58|zinc ion binding protein
Swissprots Q9P200 Q86UW9 Q9H890 Q96H69 Q6XM88 Q6XM87
Accessions AAP21881 AAS07525 EAW50382 Q86UW9 AB040961 BAA96052 AK023924 BAB14727 AK026252 AK293226 BAG56765 AY225124 AAP57518 AY225125 AAP57519 BC008856 AAH08856 BC013192 BC018555 AAH18555 BC026059 AAH26059 BC064535 AAH64535 BC093079 AAH93079 BP306192 DA003606 DA917716 DQ010329 AAY27263 DQ082728 AAZ06433 DQ082730 AAZ06435 DQ893264 ABM84190 DQ896593 ABM87592 XM_005250131 XP_005250188 XM_005250132 XP_005250189 XM_011515772 XP_011514074 XM_011515773 XP_011514075 XM_011515774 XP_011514076 XM_011515775 XP_011514077 XM_011515776 XP_011514078 XM_011515777 XP_011514079 NM_001102594 NP_001096064 NM_001102595 NP_001096065 NM_001102596 NP_001096066 NM_020892 NP_065943
Function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11564735}. Nucleus {ECO:0000269|PubMed:11564735}. Note=Predominantly cytoplasmic. Partially nuclear.
Top Pathways Notch signaling pathway

DTX2 - MBS1269603 from MyBioSource

Species Human
Accession BC008856

DTX2 - MBS1276322 from MyBioSource

Species Human
Accession BC018555

Human DTX2 cDNA clone(NM_001102594.1) - CDFH005466 from Creative Biomart

Species Human
Accession NM_001102594.1

Human DTX2 cDNA clone(NM_001102596.1) - CDFH005467 from Creative Biomart

Species Human
Accession NM_001102596.1

Human DTX2 cDNA clone(NM_001102595.1) - CDFH005468 from Creative Biomart

Species Human
Accession NM_001102595.1

Human DTX2 ORF Clone(NM_001102594.1) - CDCR347444 from Creative Biomart

Species Human
Accession NM_001102594.1

Human DTX2 ORF Clone(NM_001102594.1) - CDCR347445 from Creative Biomart

Species Human
Accession NM_001102594.1

Human DTX2 ORF Clone(NM_001102595.1) - CDCR347446 from Creative Biomart

Species Human
Accession NM_001102595.1

Human DTX2 ORF Clone(NM_001102596.1) - CDCR347447 from Creative Biomart

Species Human
Accession NM_001102596.1

Human DTX2 ORF Clone(NM_001102596.1) - CDCR347448 from Creative Biomart

Species Human
Accession NM_001102596.1

Human DTX2 ORF Clone(NM_001102595.1) - CDCR347446 from Creative biogene

Species Human

Human DTX2 ORF clone (NM_001102596.1) - CDCR057594 from Creative biogene

Species Human

Human DTX2 ORF clone (NM_001102594.1) - CDCR057596 from Creative biogene

Species Human

Human DTX2 ORF Clone (BC008856) - CDCS407562 from Creative biogene

Species Human
Accession Q86UW9

Human DTX2 ORF Clone (BC018555) - CDCS407563 from Creative biogene

Species Human
Accession Q86UW9

Human DTX2 cDNA Clone(NM_001102594.1) - CDFH005466 from Creative biogene

Species Human

Human DTX2 cDNA Clone(NM_001102596.1) - CDFH005467 from Creative biogene

Species Human

Human DTX2 cDNA Clone(NM_001102595.1) - CDFH005468 from Creative biogene

Species Human
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