DTX2

Gene Symbol DTX2
Entrez Gene 113878
Alt Symbol RNF58
Species Human
Gene Type protein-coding
Description deltex 2, E3 ubiquitin ligase
Other Description deltex homolog 2|deltex2|hDTX2|probable E3 ubiquitin-protein ligase DTX2|protein deltex-2|ring finger protein 58|zinc ion binding protein
Swissprots Q9P200 Q86UW9 Q9H890 Q96H69 Q6XM88 Q6XM87
Accessions AAP21881 AAS07525 EAW50382 Q86UW9 AB040961 BAA96052 AK023924 BAB14727 AK026252 AK293226 BAG56765 AY225124 AAP57518 AY225125 AAP57519 BC008856 AAH08856 BC013192 BC018555 AAH18555 BC026059 AAH26059 BC064535 AAH64535 BC093079 AAH93079 BP306192 DA003606 DA917716 DQ010329 AAY27263 DQ082728 AAZ06433 DQ082730 AAZ06435 DQ893264 ABM84190 DQ896593 ABM87592 XM_005250131 XP_005250188 XM_005250132 XP_005250189 XM_011515772 XP_011514074 XM_011515773 XP_011514075 XM_011515774 XP_011514076 XM_011515775 XP_011514077 XM_011515776 XP_011514078 XM_011515777 XP_011514079 NM_001102594 NP_001096064 NM_001102595 NP_001096065 NM_001102596 NP_001096066 NM_020892 NP_065943
Function Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11564735}. Nucleus {ECO:0000269|PubMed:11564735}. Note=Predominantly cytoplasmic. Partially nuclear.
Top Pathways Notch signaling pathway

Deltex-2 Antibody - 2663 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS cells, untransfected or transfected with mouse Deltex-2, using Deltex-2 Antibody.

Deltex-2 (C-12) - sc-131915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Deltex-2 (H-16) - sc-101938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
Deltex-2 (H-16): sc-101938. Western blot analysis of Deltex-2 expression in Hep G2 whole cell lysate.

Deltex-2 (N-12) - sc-131916 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DTX2 antibody - ab106332 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DTX2 antibody (ab106332) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-DTX2 antibody - ab68070 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-DTX2 antibody (ab68070) at 1/500 dilutionLane 1 : DTX2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-DTX2 antibody [EPR10916] - ab170907 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10916
Immunohistochemical analysis of paraffin-embedded Human thyroid gland carcinoma tissue, labeling DTX2 using ab170907 at a 1/100 dilution.

Anti-DTX2 antibody - C-terminal - ab197344 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Paraffin-embedded Human thyroid cancer tissue labeling DTX2 with ab197344 at 1/15 dilution.

Anti-DTX2 Antibody - LS-C310180 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DTX2 Antibody - LS-C307308 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DTX2 Antibody (aa454-503) - LS-C82459 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 0.25 ug/ml. Gel concentration: 12%.

Anti-DTX2 Antibody (aa417-430) IHC-plus™ - LS-B10327 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-DTX2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10327 concentration 5 ug/ml.

DTX2 Antibody - NBP2-13941 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DTX2 Antibody [NBP2-13941] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

DTX2 Antibody - NBP1-53119 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DTX2 Antibody [NBP1-53119] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

DTX2 Antibody - H00113878-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: DTX2 Antibody [H00113878-B01] - analysis of DTX2 expression in transfected 293T cell line by DTX2 MaxPab polyclonal antibody (B01). Lane 1: DTX2 transfected lysate (67.20 KDa). Lane 2: Non-transfected lysate.

DTX2 Antibody - H00113878-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

DTX2 Antibody - H00113878-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: DTX2 Antibody [H00113878-D01P] - Analysis of DTX2 expression in mouse brain.

DTX2 Antibody - NBP1-52144 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

DTX2 Polyclonal Antibody - bs-12394R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DTX2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12394R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DTX2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12394R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DTX2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12394R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DTX2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12394R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DTX2 Polyclonal Antibody, Cy3 Conjugated - bs-12394R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DTX2 Polyclonal Antibody, Cy5 Conjugated - bs-12394R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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