DTX2

Gene Symbol	DTX2
Entrez Gene	113878
Alt Symbol	RNF58
Species	Human
Gene Type	protein-coding
Description	deltex 2, E3 ubiquitin ligase
Other Description	deltex homolog 2|deltex2|hDTX2|probable E3 ubiquitin-protein ligase DTX2|protein deltex-2|ring finger protein 58|zinc ion binding protein
Swissprots	Q9P200 Q86UW9 Q9H890 Q96H69 Q6XM88 Q6XM87
Accessions	AAP21881 AAS07525 EAW50382 Q86UW9 AB040961 BAA96052 AK023924 BAB14727 AK026252 AK293226 BAG56765 AY225124 AAP57518 AY225125 AAP57519 BC008856 AAH08856 BC013192 BC018555 AAH18555 BC026059 AAH26059 BC064535 AAH64535 BC093079 AAH93079 BP306192 DA003606 DA917716 DQ010329 AAY27263 DQ082728 AAZ06433 DQ082730 AAZ06435 DQ893264 ABM84190 DQ896593 ABM87592 XM_005250131 XP_005250188 XM_005250132 XP_005250189 XM_011515772 XP_011514074 XM_011515773 XP_011514075 XM_011515774 XP_011514076 XM_011515775 XP_011514077 XM_011515776 XP_011514078 XM_011515777 XP_011514079 NM_001102594 NP_001096064 NM_001102595 NP_001096065 NM_001102596 NP_001096066 NM_020892 NP_065943
Function	Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11564735}. Nucleus {ECO:0000269|PubMed:11564735}. Note=Predominantly cytoplasmic. Partially nuclear.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DTX2 Antibody Blocking Peptide - LS-E27209 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DTX2 Antibody Blocking Peptide - LS-E15928 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DTX2-Antibody-C-term-Blocking-Peptide - BP9002b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DTX2/Deltext-2 blocking peptide - GTX88299-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Rat, Bovine

Goat anti DTX2 antibody Immunizing peptide - orb15516 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

DTX2 Blocking Peptide - 33R-2305 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DTX2 Peptide - AC21-2030-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DTX2 Peptide - 42-781P from ProSci Category Peptide

DTX2 fusion protein - Ag11791 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

DTX2 fusion protein - Ag12022 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DTX2 fusion protein - Ag4376 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DTX2 fusion protein - ag1050 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human DTX2, GST-tagged - DTX2-12191H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Protein deltex-2(DTX2) - CSB-YP803123HU CSB-EP803123HU CSB-BP803123HU CSB-MP803123HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DTX2 Protein - abx164338 from Abbexa Category Protein Species Human, Mouse, Rat

DTX2 / RNF58 (transcript variant 1) - TP303717 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DTX2 / RNF58 (transcript variant 2) - TP312997 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DTX2 / RNF58 (transcript variant 3) - TP313418 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DTX2/Deltext-2, Peptide - MBS426726 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat, Bovine

DTX2 Recombinant Protein Antigen - NBP2-13941PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DTX2 Peptide, Human - M34GP04585H from Creative Peptides Category Peptide Source Synthetic. Species Human

Protein deltex-2 (DTX2), Recombinant Protein - MBS1393258 from MyBioSource Category Protein Prices $1,415.00, $1,415.00, $1,645.00, $1,645.00, $2,395.00, $2,395.00, $2,840.00, $2,840.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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