| Gene Symbol |
MICAL1
|
| Entrez Gene |
64780
|
| Alt Symbol |
MICAL, MICAL-1, NICAL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule associated monooxygenase, calponin and LIM domain containing 1
|
| Other Description |
CasL interacting molecule|NEDD9-interacting protein with calponin homology and LIM domains|microtubule associated monoxygenase, calponin and LIM domain containing 1|molecule interacting with CasL protein 1|protein-methionine sulfoxide oxidase MICAL1
|
| Swissprots |
B7Z3R5 Q9HAA1 E1P5F0 Q96G47 Q9H7I0 Q7Z633 Q9H6X6 Q9UFF7 Q8IVS9 Q8TDZ2
|
| Accessions |
EAW48339 EAW48340 EAW48341 EAW48342 EAW48343 EAW48344 EAW48345 Q8TDZ2 AB048948 BAB86289 AK021999 BAB13949 AK024500 BAB15790 AK025392 BAB15124 AK160384 BAD18727 AK225049 AK296284 BAH12301 AL122098 CAB59266 BC009972 AAH09972 BC036514 BC042144 AAH42144 BC052983 AAH52983 NM_001159291 NP_001152763 NM_001286613 NP_001273542 NM_022765 NP_073602
|
| Function |
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. {ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000305}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytoskeleton.
|
| Tissue Specificity |
Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. {ECO:0000269|PubMed:11827972}.
|