Gene Symbol | MICAL1 |
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Entrez Gene | 64780 |
Alt Symbol | MICAL, MICAL-1, NICAL |
Species | Human |
Gene Type | protein-coding |
Description | microtubule associated monooxygenase, calponin and LIM domain containing 1 |
Other Description | CasL interacting molecule|NEDD9-interacting protein with calponin homology and LIM domains|microtubule associated monoxygenase, calponin and LIM domain containing 1|molecule interacting with CasL protein 1|protein-methionine sulfoxide oxidase MICAL1 |
Swissprots | B7Z3R5 Q9HAA1 E1P5F0 Q96G47 Q9H7I0 Q7Z633 Q9H6X6 Q9UFF7 Q8IVS9 Q8TDZ2 |
Accessions | EAW48339 EAW48340 EAW48341 EAW48342 EAW48343 EAW48344 EAW48345 Q8TDZ2 AB048948 BAB86289 AK021999 BAB13949 AK024500 BAB15790 AK025392 BAB15124 AK160384 BAD18727 AK225049 AK296284 BAH12301 AL122098 CAB59266 BC009972 AAH09972 BC036514 BC042144 AAH42144 BC052983 AAH52983 NM_001159291 NP_001152763 NM_001286613 NP_001273542 NM_022765 NP_073602 |
Function | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (Probable). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. {ECO:0000269|PubMed:18305261, ECO:0000269|PubMed:21864500, ECO:0000305}. |
Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. |
Tissue Specificity | Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. {ECO:0000269|PubMed:11827972}. |
MICAL1 (C-16) - sc-161855 from Santa Cruz Biotechnology
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MICAL1 (K-13) - sc-161856 from Santa Cruz Biotechnology
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MICAL1 (P-20) - sc-161858 from Santa Cruz Biotechnology
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Anti-MICAL1 antibody - ab67640 from Abcam
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Anti-MICAL1 antibody [1C2] - ab119034 from Abcam
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Anti-MICAL1 antibody [EPR11486] - ab181145 from Abcam
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Anti-MICAL1 / MICAL Antibody (clone 2H1) IHC-plus⢠- LS-B11772 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (clone 4D1) - LS-C115725 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (clone 6H10) - LS-C115723 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (clone 6H4) - LS-C115720 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (clone 4B1) - LS-C115754 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody - LS-C309219 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (C-Terminus) - LS-C145577 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (clone 1C2) - LS-C115719 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (clone 6G2) - LS-C115722 from LifeSpan Bioscience
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Anti-MICAL1 / MICAL Antibody (clone 3C6) - LS-C115755 from LifeSpan Bioscience
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MICAL1 Antibody (6H4) - NBP2-03135 from Novus Biologicals
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MICAL1 Antibody - NBP2-38154 from Novus Biologicals
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MICAL1 Antibody - NBP2-38153 from Novus Biologicals
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MICAL1 Antibody - H00064780-B01P from Novus Biologicals
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MICAL1 Antibody - NBP2-17287 from Novus Biologicals
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MICAL1 Antibody (3D12) - H00064780-M06-100ug from Novus Biologicals
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MICAL1 Polyclonal Antibody - bs-11525R from Bioss
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MICAL1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11525R-A350 from Bioss
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MICAL1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11525R-A488 from Bioss
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