| Gene Symbol |
GDF2
|
| Entrez Gene |
2658
|
| Alt Symbol |
BMP-9, BMP9, HHT5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth differentiation factor 2
|
| Other Description |
GDF-2|bone morphogenetic protein 9|growth/differentiation factor 2
|
| Swissprots |
Q9UK05 Q5VSQ9 Q9Y571
|
| Accessions |
EAW50660 Q9UK05 AF156891 AAD40309 AF188285 AAD56960 AK314956 BAG37460 BC069643 AAH69643 BC074921 AAH74921 EU446620 ABZ92149 EU446952 ABZ92481 XM_006717761 XP_006717824 NM_016204 NP_057288
|
| Function |
Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. {ECO:0000269|PubMed:18309101, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:23300529}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:18309101}.
|
