Gene Symbol | GDF2 |
---|---|
Entrez Gene | 2658 |
Alt Symbol | BMP-9, BMP9, HHT5 |
Species | Human |
Gene Type | protein-coding |
Description | growth differentiation factor 2 |
Other Description | GDF-2|bone morphogenetic protein 9|growth/differentiation factor 2 |
Swissprots | Q9UK05 Q5VSQ9 Q9Y571 |
Accessions | EAW50660 Q9UK05 AF156891 AAD40309 AF188285 AAD56960 AK314956 BAG37460 BC069643 AAH69643 BC074921 AAH74921 EU446620 ABZ92149 EU446952 ABZ92481 XM_006717761 XP_006717824 NM_016204 NP_057288 |
Function | Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. {ECO:0000269|PubMed:18309101, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:23300529}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:18309101}. |