Gene Symbol | GDF2 |
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Entrez Gene | 2658 |
Alt Symbol | BMP-9, BMP9, HHT5 |
Species | Human |
Gene Type | protein-coding |
Description | growth differentiation factor 2 |
Other Description | GDF-2|bone morphogenetic protein 9|growth/differentiation factor 2 |
Swissprots | Q9UK05 Q5VSQ9 Q9Y571 |
Accessions | EAW50660 Q9UK05 AF156891 AAD40309 AF188285 AAD56960 AK314956 BAG37460 BC069643 AAH69643 BC074921 AAH74921 EU446620 ABZ92149 EU446952 ABZ92481 XM_006717761 XP_006717824 NM_016204 NP_057288 |
Function | Potent circulating inhibitor of angiogenesis. Could be involved in bone formation. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. {ECO:0000269|PubMed:18309101, ECO:0000269|PubMed:22799562, ECO:0000269|PubMed:23300529}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:18309101}. |
BMP-9 CRISPR/Cas9 KO Plasmid (h) - sc-402887 from Santa Cruz Biotechnology
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BMP-9 HDR Plasmid (h) - sc-402887-HDR from Santa Cruz Biotechnology
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BMP-9 Double Nickase Plasmid (h) - sc-402887-NIC from Santa Cruz Biotechnology
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BMP-9 Double Nickase Plasmid (h2) - sc-402887-NIC-2 from Santa Cruz Biotechnology
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BMP-9 CRISPR Activation Plasmid (h) - sc-402887-ACT from Santa Cruz Biotechnology
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BMP-9 CRISPR Activation Plasmid (h2) - sc-402887-ACT-2 from Santa Cruz Biotechnology
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BMP-9 Lentiviral Activation Particles (h) - sc-402887-LAC from Santa Cruz Biotechnology
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BMP-9 Lentiviral Activation Particles (h2) - sc-402887-LAC-2 from Santa Cruz Biotechnology
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BMP-9 siRNA (h) - sc-39756 from Santa Cruz Biotechnology
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BMP-9 shRNA Plasmid (h) - sc-39756-SH from Santa Cruz Biotechnology
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BMP-9 shRNA (h) Lentiviral Particles - sc-39756-V from Santa Cruz Biotechnology
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BMP-9 RNAi - H00002658-R01 from Novus Biologicals
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MISSION® esiRNA - EHU150141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9213 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9213 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04945 from Sigma-Aldrich
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GDF2 siRNA (Human) - CRH1771 from Cohesion Biosciences
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GDF2 - MBS8220866 from MyBioSource
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shRNA set against Human GDF2 (NM_016204.1) - SHH300290 from Creative biogene
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shRNA set against Human GDF2(NM_016204.1) - SHH081191 from Creative biogene
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Human GDF2 siRNA - orb262273 from Biorbyt
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GDF2 shRNA Plasmid (Human) - CHH1771 from Cohesion Biosciences
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GDF2 miRNA 3'UTR clone - MiUTR1H-03997 from Creative biogene
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