| Gene Symbol |
NCEH1
|
| Entrez Gene |
57552
|
| Alt Symbol |
AADACL1, NCEH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neutral cholesterol ester hydrolase 1
|
| Other Description |
arylacetamide deacetylase-like 1
|
| Swissprots |
B7ZAW6 F5H7K4 Q86WZ1 B7Z3A1 B7Z2K4 Q9P2I4 B7Z5U2 Q6PIU2 B7Z906
|
| Accessions |
EAW78462 Q6PIU2 AB037784 BAA92601 AK294811 BAH11890 AK295641 BAH12137 AK299422 BAH13028 AK304253 BAH14142 AK316431 BAH14802 AL512752 BC028734 AAH28734 BC047588 AAH47588 BG701753 BP395319 DA856205 DB289027 DC306836 NM_001146276 NP_001139748 NM_001146277 NP_001139749 NM_001146278 NP_001139750 NM_020792 NP_065843
|
| Function |
Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. {ECO:0000269|PubMed:17052608}.
|
| Subcellular Location |
Membrane {ECO:0000305|PubMed:12149457}; Single-pass type II membrane protein {ECO:0000305|PubMed:12149457}. Microsome {ECO:0000250}.
|
| Tissue Specificity |
Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines. {ECO:0000269|PubMed:12149457, ECO:0000269|PubMed:18782767}.
|
| Top Pathways |
Bile secretion
|