NCEH1

Gene Symbol NCEH1
Entrez Gene 57552
Alt Symbol AADACL1, NCEH
Species Human
Gene Type protein-coding
Description neutral cholesterol ester hydrolase 1
Other Description arylacetamide deacetylase-like 1
Swissprots B7ZAW6 F5H7K4 Q86WZ1 B7Z3A1 B7Z2K4 Q9P2I4 B7Z5U2 Q6PIU2 B7Z906
Accessions EAW78462 Q6PIU2 AB037784 BAA92601 AK294811 BAH11890 AK295641 BAH12137 AK299422 BAH13028 AK304253 BAH14142 AK316431 BAH14802 AL512752 BC028734 AAH28734 BC047588 AAH47588 BG701753 BP395319 DA856205 DB289027 DC306836 NM_001146276 NP_001139748 NM_001146277 NP_001139749 NM_001146278 NP_001139750 NM_020792 NP_065843
Function Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. {ECO:0000269|PubMed:17052608}.
Subcellular Location Membrane {ECO:0000305|PubMed:12149457}; Single-pass type II membrane protein {ECO:0000305|PubMed:12149457}. Microsome {ECO:0000250}.
Tissue Specificity Expressed in monocyte-derived macrophages. Up- regulated in invasive melanoma and breast carcinoma cell lines. {ECO:0000269|PubMed:12149457, ECO:0000269|PubMed:18782767}.
Top Pathways Bile secretion

AADACL1 CRISPR/Cas9 KO Plasmid (h) - sc-406038 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 HDR Plasmid (h) - sc-406038-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 Double Nickase Plasmid (h) - sc-406038-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 Double Nickase Plasmid (h2) - sc-406038-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 CRISPR Activation Plasmid (h) - sc-406038-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 CRISPR Activation Plasmid (h2) - sc-406038-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 Lentiviral Activation Particles (h) - sc-406038-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 Lentiviral Activation Particles (h2) - sc-406038-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AADACL1 siRNA (h) - sc-78428 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AADACL1 shRNA Plasmid (h) - sc-78428-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AADACL1 shRNA (h) Lentiviral Particles - sc-78428-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU032001 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15012 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15012 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NCEH1 siRNA (Human) - CRJ1530 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NCEH1 (NM_020792.4) - SHH349924 from Creative biogene

Category siRNA
Species Reactivities Human

NCEH1 shRNA Plasmid (Human) - CHJ1530 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NCEH1 miRNA 3'UTR clone - MiUTR4H-TG05879 from Creative biogene

Species Reactivities Human
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