Gene Symbol | LRIG3 |
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Entrez Gene | 121227 |
Alt Symbol | LIG3 |
Species | Human |
Gene Type | protein-coding |
Description | leucine-rich repeats and immunoglobulin-like domains 3 |
Other Description | LIG-3|leucine-rich repeats and immunoglobulin-like domains protein 3 |
Swissprots | Q6UXL7 Q8NC72 Q6UXM1 |
Accessions | EAW97094 EAW97095 Q6UXM1 AK074921 BAC11295 AK130083 AK292857 BAF85546 AK301162 BAG62752 AL833710 AY358288 AAQ88655 AY358295 AAQ88662 AY505340 AAR98629 BC012380 BC126169 AAI26170 BC126171 AAI26172 BC143960 DA456424 XM_011537893 XP_011536195 NM_001136051 NP_001129523 NM_153377 NP_700356 |
Function | May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:15203213}. |
LRIG3 CRISPR/Cas9 KO Plasmid (h) - sc-404445 from Santa Cruz Biotechnology
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LRIG3 HDR Plasmid (h) - sc-404445-HDR from Santa Cruz Biotechnology
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LRIG3 Double Nickase Plasmid (h) - sc-404445-NIC from Santa Cruz Biotechnology
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LRIG3 Double Nickase Plasmid (h2) - sc-404445-NIC-2 from Santa Cruz Biotechnology
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LRIG3 CRISPR Activation Plasmid (h) - sc-404445-ACT from Santa Cruz Biotechnology
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LRIG3 CRISPR Activation Plasmid (h2) - sc-404445-ACT-2 from Santa Cruz Biotechnology
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LRIG3 Lentiviral Activation Particles (h) - sc-404445-LAC from Santa Cruz Biotechnology
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LRIG3 Lentiviral Activation Particles (h2) - sc-404445-LAC-2 from Santa Cruz Biotechnology
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LRIG3 siRNA (h) - sc-106184 from Santa Cruz Biotechnology
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LRIG3 shRNA Plasmid (h) - sc-106184-SH from Santa Cruz Biotechnology
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LRIG3 shRNA (h) Lentiviral Particles - sc-106184-V from Santa Cruz Biotechnology
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LRIG3 RNAi - H00121227-R01 from Novus Biologicals
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DNA Ligase III RNAi - H00003980-R01 from Novus Biologicals
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DNA Ligase III RNAi - H00003980-R02 from Novus Biologicals
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MISSION® esiRNA - EHU043271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12682 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12682 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03054 from Sigma-Aldrich
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LRIG3 siRNA (Human) - CRJ4661 from Cohesion Biosciences
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shRNA set against Human Lrig3 (NM_153377.4) - SHH333887 from Creative biogene
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Human LRIG3 siRNA - orb275162 from Biorbyt
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LRIG3 shRNA Plasmid (Human) - CHJ4661 from Cohesion Biosciences
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LRIG3 miRNA 3'UTR clone - MiUTR3H-10285 from Creative biogene
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LRIG3 miRNA 3'UTR clone - MiUTR3H-10286 from Creative biogene
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