| Gene Symbol |
KLF15
|
| Entrez Gene |
28999
|
| Alt Symbol |
KKLF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Kruppel-like factor 15
|
| Other Description |
Krueppel-like factor 15|kidney-enriched Kruppel-like factor|kidney-enriched krueppel-like factor
|
| Swissprots |
Q9UIH9
|
| Accessions |
EAW79367 Q9UIH9 AB029254 BAA88561 BC036733 AAH36733 BX649049 DQ890911 ABM81837 DQ894062 ABM84988 XM_005247400 XP_005247457 XM_011512743 XP_011511045 NM_014079 NP_054798
|
| Function |
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289}.
|
| Tissue Specificity |
Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues. {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:22493483}.
|
