KLF15

Gene Symbol KLF15
Entrez Gene 28999
Alt Symbol KKLF
Species Human
Gene Type protein-coding
Description Kruppel-like factor 15
Other Description Krueppel-like factor 15|kidney-enriched Kruppel-like factor|kidney-enriched krueppel-like factor
Swissprots Q9UIH9
Accessions EAW79367 Q9UIH9 AB029254 BAA88561 BC036733 AAH36733 BX649049 DQ890911 ABM81837 DQ894062 ABM84988 XM_005247400 XP_005247457 XM_011512743 XP_011511045 NM_014079 NP_054798
Function Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289}.
Tissue Specificity Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues. {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:22493483}.

KLF15 (A-5) - sc-271675 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
KLF15 (A-5): sc-271675. Western blot analysis of KLF15 expression in non-transfected: sc-117752 (A) and human KLF15 transfected: sc-115194 (B) 293T whole cell lysates.

KLF15 (A-12) - sc-393627 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
KLF15 (A-12): sc-393627. Western blot analysis of KLF15 expression in non-transfected: sc-117752 (A) and human KLF15 transfected: sc-115194 (B) 293T whole cell lysates.

KLF15 (H-87) - sc-367391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KLF15 (H-87): sc-367391. Western blot analysis of KLF15 expression in non-transfected: sc-117752 (A) and human KLF15 transfected: sc-115194 (B) 293T whole cell lysates.

KLF15 (C-14) - sc-34826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KLF15 (C-14): sc-34826. Western blot analysis of KLF15 expression in KNRK nuclear extract.

KLF15 (N-16) - sc-34827 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KLF15 (N-16): sc-34827. Western blot analysis of KLF15 expression in non-transfected: sc-117752 (A) and human KLF15 transfected: sc-115194 (B) 293T whole cell lysates.

Anti-KLF15 antibody - ab2647 from Abcam

Prices $382.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-KLF15 antibody - ab22851 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-KLF15 antibody (ab22851) at 4 µg/ml + HepG2 cell lysate.SecondaryHRP conjugated anti-Rabbit IgG should be diluted in 1/50,000 - 100,000developed using the ECL techniquePerformed under reducing conditions.

Anti-KLF15 antibody - ab167192 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-KLF15 antibody (ab167192) at 1 µg/mlLane 1 : Lysate of 293T cells transfected with KLF15Lane 2 : Lysate of 293T cells (non-transfected) Lysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse HRP conjugated antibody at 1/2500 dilution

Anti-KLF15 antibody - ab109426 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KLF15 antibody (ab109426) at 1 µg/ml (Milk Blocking (3%))Lane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KLF15 antibody [2G8] - ChIP Grade - ab81604 from Abcam

Host Mouse
Clonality Monoclonal
Clone 2G8
Anti-KLF15 antibody [2G8] - ChIP Grade (ab81604) at 1/500 dilution + HepG2 cell lysate

Anti-KLF15 antibody [EPR14131] - N-terminal - ab185958 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14131
All lanes : Anti-KLF15 antibody [EPR14131] - N-terminal (ab185958) at 1/10000 dilutionLane 1 : HepG2 cell lysateLane 2 : 293 cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-KLF15 antibody [EPR14131] - N-terminal (Alexa Fluor® 488) - ab200758 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14131
ab200758 staining KLF15 in HepG2 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200758 at a 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HepG2 cells fixed with 100% methanol (5 min).

Anti-KLF15 antibody [EPR14131] - N-terminal (Alexa Fluor® 647) - ab200764 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14131
ab200764 staining KLF15 in HepG2 cells. The cells were fixed with 100% methanol (5 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab200764 at a 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at a 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HepG2 cells fixed with 4% formaldehyde (10 min).

Anti-KLF15 antibody - C-terminal - ab173797 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-KLF15 antibody - C-terminal (ab173797) at 1/100 dilution + 293 cell line lysates at 35 µg

Anti-KLF15 antibody - N-terminal - ab154078 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KLF15 antibody - N-terminal (ab154078) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-KLF15 Antibody (aa372-398, AP) - LS-C236858 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLF15 Antibody (aa372-398, APC) - LS-C236859 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLF15 Antibody (aa372-398, Biotin) - LS-C236860 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLF15 Antibody (aa372-398, FITC) - LS-C236861 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLF15 Antibody (aa372-398, PE) - LS-C236863 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLF15 Antibody (aa372-398, Azide-free, HRP) - LS-C248654 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KLF15 Antibody (aa1-79) - LS-C308656 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KLF15 Antibody - LS-C310823 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KLF15 Antibody (aa45-94) - LS-C30995 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
KLF15 antibody LS-C30995 was used in IHC to stain formalin-fixed, paraffin-embedded human liver.

Anti-KLF15 Antibody (clone 2G8) - LS-C108831 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2G8
Western blot using KLF15 mouse monoclonal antibody against HepG2 (1) and SMMC-7721 (2) cell lysate.
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