Gene Symbol | KLF15 |
---|---|
Entrez Gene | 28999 |
Alt Symbol | KKLF |
Species | Human |
Gene Type | protein-coding |
Description | Kruppel-like factor 15 |
Other Description | Krueppel-like factor 15|kidney-enriched Kruppel-like factor|kidney-enriched krueppel-like factor |
Swissprots | Q9UIH9 |
Accessions | EAW79367 Q9UIH9 AB029254 BAA88561 BC036733 AAH36733 BX649049 DQ890911 ABM81837 DQ894062 ABM84988 XM_005247400 XP_005247457 XM_011512743 XP_011511045 NM_014079 NP_054798 |
Function | Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289}. |
Tissue Specificity | Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues. {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:22493483}. |
Human KLF15 full length protein - ab131876 from Abcam
|
||||||||||
Human KLF15 peptide - ab22927 from Abcam
|
||||||||||
KLF15 peptide - ab200413 from Abcam
|
||||||||||
KLF15 Antibody Blocking Peptide - LS-E5607 from LifeSpan Bioscience
|
||||||||||
KLF15 Antibody Blocking Peptide - LS-E25368 from LifeSpan Bioscience
|
||||||||||
KLF15 Antibody Blocking Peptide - LS-E11127 from LifeSpan Bioscience
|
||||||||||
Recombinant Human KLF15 Protein - H00028999-P01 from Novus Biologicals
|
||||||||||
Recombinant Human KLF15 Protein - H00028999-Q01 from Novus Biologicals
|
||||||||||
KLF15-Antibody-C-term-Blocking-Peptide - BP18136b from Abgent, a WuXi AppTec company
|
||||||||||
KLF15 blocking peptide - GTX89919-PEP from GeneTex
|
||||||||||
KLF15 Peptide - AC21-0196-P from Abcore
|
||||||||||
KLF15 - H00028999-P01-10 from Acris Antibodies
|
||||||||||
KLF15 - H00028999-P01-25 from Acris Antibodies
|
||||||||||
KLF15 - H00028999-Q01-10 from Acris Antibodies
|
||||||||||
KLF15 - H00028999-Q01-25 from Acris Antibodies
|
||||||||||
KLF15 Peptide - 45-803P from ProSci
|
||||||||||
KLF15 fusion protein - ag4690 from Proteintech Group
|
||||||||||
KLF15 fusion protein - ag4864 from Proteintech Group
|
||||||||||
Recombinant Kruppel Like Factor 15 (KLF15) - RPD370Hu01 from Uscn Life Science Inc.
|
||||||||||
Recombinant Kruppel Like Factor 15 (KLF15) - RPD370Hu01 from Cloud-clone
|
||||||||||
Recombinant Human Krueppel-like factor 15(KLF15) - CSB-YP883433HU CSB-EP883433HU CSB-BP883433HU CSB-MP883433HU from Cusabio
|
||||||||||
KLF15 - TP307523 from Acris Antibodies
|
||||||||||
KLF15, Peptide - MBS426377 from MyBioSource
|
||||||||||
KLF15 Recombinant Protein Antigen - NBP1-82872PEP from Novus Biologicals
|
||||||||||
KLF15 Peptide, Human - M34GP08247H from Creative Peptides
|