GPSM1

Gene Symbol GPSM1
Entrez Gene 26086
Alt Symbol AGS3
Species Human
Gene Type protein-coding
Description G-protein signaling modulator 1
Other Description G-protein signalling modulator 1 (AGS3-like, C. elegans)|G-protein-signaling modulator 1|activator of G-protein signaling 3
Swissprots Q9UFS8 Q969T1 Q86SR5 Q86YR5 A9Z1X4 B1B0W3
Accessions EAW88216 EAW88217 EAW88218 Q86YR5 AL117478 CAB55951 AL545250 AY173053 AAO17260 BC009943 BC009979 AAH09979 BC017257 BC017353 AAH17353 BC048343 AAH48343 BI766024 BQ214873 BU631041 XM_011518498 XP_011516800 NM_001145638 NP_001139110 NM_001145639 NP_001139111 NM_001200003 NP_001186932 NM_015597 NP_056412
Function Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}.
Subcellular Location Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity Expressed in intestinal cells. {ECO:0000269|PubMed:12642577}.
Top Pathways Cocaine addiction

AGS3 (A-20) - sc-16393 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AGS3 (A-20): sc-16393. Western blot analysis of AGS3 expression in rat brain tissue extract.

AGS3 (C-14) - sc-249915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

AGS3 (G-2) - sc-271721 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
AGS3 (G-2): sc-271721. Western blot analysis of AGS3 expression in non-transfected: sc-117752 (A) and mouse AGS3 transfected: sc-126400 (B) 293T whole cell lysates and rat brain tissue extract (C).

AGS3 (N-16) - sc-249913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

AGS3 (R-125) - sc-33222 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AGS3 (R-125): sc-33222. Western blot analysis of AGS3 expression in non-transfected: sc-117752 (A) and mouse AGS3 transfected: sc-126400 (B) 293T whole cell lysates and rat brain tissue extract (C).

AGS3 (T-20) - sc-249914 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-GPSM1 antibody - ab111022 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 antibody - ab176806 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation analysis of 293T whole cell lysate (1 mg for IP; 20% of IP loaded). 1) ab176806 used at 6 µg/mg lysate. 2) control IgG. For blotting an anti-GPSM1 antibody was used at 1 µg/ml. Chemiluminescence with an exposure time of 30 seconds.

Anti-GPSM1 antibody - ab113040 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-GPSM1 antibody (ab113040) at 1/100 dilution + NCI-H460 cell line lysate at 35 µg

Anti-GPSM1 / AGS3 Antibody (aa439-468) - LS-C166649 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
GPSM1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human rectum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-GPSM1 / AGS3 Antibody (Internal) - LS-C145166 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody (aa439-468, AP) - LS-C235960 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody (aa439-468, APC) - LS-C235961 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody (aa439-468, Biotin) - LS-C235962 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody (aa444-493) - LS-C152013 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
AGS3 antibody Western Blot of NCI-H226.

Anti-GPSM1 / AGS3 Antibody (aa439-468, FITC) - LS-C235964 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody (aa439-468, PE) - LS-C246716 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody (aa439-468, Azide-free, HRP) - LS-C249129 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody (aa446-476) - LS-C321772 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GPSM1 / AGS3 Antibody - LS-C308309 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-GPSM1 / AGS3 Antibody (aa450-500) - LS-C290424 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human AGS3 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-AGS3 antibody used for IP at 6 ug/mg lysate. AGS3 was less efficiently immunoprecipitated by rabbit anti-AGS3 antibody BL13542, which recognizes a downstream epitope. For blotting immunoprecipitated AGS3, BL13542 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

GPSM1 Antibody - NBP1-91968 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: GPSM1 Antibody [NBP1-91968] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

GPSM1 Antibody - H00026086-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: GPSM1 Antibody [H00026086-B01P] - Analysis of GPSM1 expression in rat brain.

GPSM1 Antibody (1B3) - H00026086-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B3
Sandwich ELISA: GPSM1 Antibody (1B3) [H00026086-M01] - Detection limit for recombinant GST tagged GPSM1 is 3 ng/ml as a capture antibody.

GPSM1 Polyclonal Antibody - bs-7865R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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