| Gene Symbol | GPSM1 |
|---|---|
| Entrez Gene | 26086 |
| Alt Symbol | AGS3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | G-protein signaling modulator 1 |
| Other Description | G-protein signalling modulator 1 (AGS3-like, C. elegans)|G-protein-signaling modulator 1|activator of G-protein signaling 3 |
| Swissprots | Q9UFS8 Q969T1 Q86SR5 Q86YR5 A9Z1X4 B1B0W3 |
| Accessions | EAW88216 EAW88217 EAW88218 Q86YR5 AL117478 CAB55951 AL545250 AY173053 AAO17260 BC009943 BC009979 AAH09979 BC017257 BC017353 AAH17353 BC048343 AAH48343 BI766024 BQ214873 BU631041 XM_011518498 XP_011516800 NM_001145638 NP_001139110 NM_001145639 NP_001139111 NM_001200003 NP_001186932 NM_015597 NP_056412 |
| Function | Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}. |
| Subcellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Tissue Specificity | Expressed in intestinal cells. {ECO:0000269|PubMed:12642577}. |
| Top Pathways | Cocaine addiction |
AGS3 CRISPR/Cas9 KO Plasmid (h) - sc-402802 from Santa Cruz Biotechnology
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AGS3 HDR Plasmid (h) - sc-402802-HDR from Santa Cruz Biotechnology
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AGS3 Double Nickase Plasmid (h) - sc-402802-NIC from Santa Cruz Biotechnology
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AGS3 Double Nickase Plasmid (h2) - sc-402802-NIC-2 from Santa Cruz Biotechnology
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AGS3 CRISPR Activation Plasmid (h) - sc-402802-ACT from Santa Cruz Biotechnology
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AGS3 CRISPR Activation Plasmid (h2) - sc-402802-ACT-2 from Santa Cruz Biotechnology
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AGS3 Lentiviral Activation Particles (h) - sc-402802-LAC from Santa Cruz Biotechnology
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AGS3 Lentiviral Activation Particles (h2) - sc-402802-LAC-2 from Santa Cruz Biotechnology
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AGS3 siRNA (h) - sc-44441 from Santa Cruz Biotechnology
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AGS3 shRNA Plasmid (h) - sc-44441-SH from Santa Cruz Biotechnology
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AGS3 shRNA (h) Lentiviral Particles - sc-44441-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9640 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9640 from Sigma-Aldrich
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GPSM1 siRNA (Human) - CRH8700 from Cohesion Biosciences
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GPSM1 - MBS8203091 from MyBioSource
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shRNA set against Human GPSM1 (NM_015597.4) - SHH307302 from Creative biogene
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GPSM1 shRNA Plasmid (Human) - CHH8700 from Cohesion Biosciences
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GPSM1 miRNA 3'UTR clone - MiUTR3H-10637 from Creative biogene
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GPSM1 miRNA 3'UTR clone - MiUTR3H-10638 from Creative biogene
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GPSM1 miRNA 3'UTR clone - MiUTR3H-10639 from Creative biogene
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