| Gene Symbol |
GPSM1
|
| Entrez Gene |
26086
|
| Alt Symbol |
AGS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G-protein signaling modulator 1
|
| Other Description |
G-protein signalling modulator 1 (AGS3-like, C. elegans)|G-protein-signaling modulator 1|activator of G-protein signaling 3
|
| Swissprots |
Q9UFS8 Q969T1 Q86SR5 Q86YR5 A9Z1X4 B1B0W3
|
| Accessions |
EAW88216 EAW88217 EAW88218 Q86YR5 AL117478 CAB55951 AL545250 AY173053 AAO17260 BC009943 BC009979 AAH09979 BC017257 BC017353 AAH17353 BC048343 AAH48343 BI766024 BQ214873 BU631041 XM_011518498 XP_011516800 NM_001145638 NP_001139110 NM_001145639 NP_001139111 NM_001200003 NP_001186932 NM_015597 NP_056412
|
| Function |
Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}.
|
| Subcellular Location |
Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
|
| Tissue Specificity |
Expressed in intestinal cells. {ECO:0000269|PubMed:12642577}.
|
| Top Pathways |
Cocaine addiction
|