| Gene Symbol |
ZNF224
|
| Entrez Gene |
7767
|
| Alt Symbol |
BMZF-2, BMZF2, KOX22, ZNF255, ZNF27
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 224
|
| Other Description |
bone marrow zinc finger 2|zinc finger 2, bone marrow|zinc finger protein 233|zinc finger protein 255|zinc finger protein 27 (KOX 22)|zinc finger protein KOX22|zinc finger protein ZNF255
|
| Swissprots |
Q9Y2P6 P17033 Q86V10 A6NFW9 Q9NZL3 Q9UID9 Q8IZC8
|
| Accessions |
AAF24968 AAG23845 EAW57250 EAW57251 EAW57252 EAW57253 EAW57254 Q9NZL3 AF067164 AAD32448 AF187990 AAF04106 AK292500 BAF85189 AY148489 AAN61121 BC002889 AAH02889 BC051902 AAH51902 DA245440 EU446733 ABZ92262 X52353 CAA36579 XM_005259221 XP_005259278 NM_013398 NP_037530
|
| Function |
May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12239212, ECO:0000269|PubMed:20587513, ECO:0000269|PubMed:23665872}. Note=Colocalizes with DEPDC1A at the nucleus.
|
| Tissue Specificity |
Ubiquitous. Mainly expressed in fetal tissues. {ECO:0000269|PubMed:12239212}.
|