Gene Symbol | SMOX |
---|---|
Entrez Gene | 54498 |
Alt Symbol | C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO |
Species | Human |
Gene Type | protein-coding |
Description | spermine oxidase |
Other Description | flavin containing amine oxidase|flavin-containing spermine oxidase|polyamine oxidase 1|putative cyclin G1 interacting protein |
Swissprots | Q5TE26 Q9BW38 Q5TE27 D3DVZ4 Q9NPY1 Q9H6H1 Q8IX00 A2A2P5 Q96QT3 A2A2P6 Q6UY28 A8BE87 Q96LC4 Q9NWM0 Q9NP51 Q9NPY2 Q96LC3 |
Accessions | EAX10457 EAX10458 EAX10459 EAX10460 EAX10461 EAX10462 EAX10463 Q9NWM0 AF519179 AAN77119 AK000753 BAA91360 AK025938 BAB15288 AK127286 AK293485 BAG56974 AL162058 CAB82396 AW136764 AY033889 AAK55763 AY033890 AAK55764 AY033891 AAK55765 AY358104 AAQ88471 BC000669 AAH00669 BG480614 BG679874 EF032141 ABM01872 U61836 XM_011529261 XP_011527563 NM_001270691 NP_001257620 NM_175839 NP_787033 NM_175840 NP_787034 NM_175841 NP_787035 NM_175842 NP_787036 |
Function | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
Subcellular Location | Isoform 6: Cytoplasm. Nucleus. |
Tissue Specificity | Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO:0000269|PubMed:18422650}. |
Top Pathways | Arginine and proline metabolism, beta-Alanine metabolism |
SMO / Smoothened Antibody Blocking Peptide - LS-E4085 from LifeSpan Bioscience
|
||||||||||
SMO / Smoothened Antibody Blocking Peptide - LS-E26178 from LifeSpan Bioscience
|
||||||||||
SMO / Smoothened Antibody Blocking Peptide - LS-E25996 from LifeSpan Bioscience
|
||||||||||
SMO / Smoothened Antibody Blocking Peptide - LS-E28591 from LifeSpan Bioscience
|
||||||||||
SMO / Smoothened Antibody Blocking Peptide - LS-E28592 from LifeSpan Bioscience
|
||||||||||
SMOX / PAO Antibody Blocking Peptide - LS-E23996 from LifeSpan Bioscience
|
||||||||||
Recombinant Human Smoothened Protein - H00006608-Q02 from Novus Biologicals
|
||||||||||
Recombinant Human Smoothened Protein - H00006608-Q01 from Novus Biologicals
|
||||||||||
Recombinant Human Smoothened Protein - H00006608-Q03 from Novus Biologicals
|
||||||||||
Smoothened Recombinant Protein - H00006608-G01 from Novus Biologicals
|
||||||||||
SMOX fusion protein - ag7035 from Proteintech Group
|
||||||||||
Recombinant Human SMOX, GST-tagged - SMOX-2820H from Creative Biomart
|
||||||||||
Recombinant Spermine Oxidase (SMOX) - RPC852Hu01 from Uscn Life Science Inc.
|
||||||||||
Recombinant Spermine Oxidase (SMOX) - RPC852Mu01 from Uscn Life Science Inc.
|
||||||||||
Recombinant Spermine Oxidase (SMOX) - RPC852Mu02 from Uscn Life Science Inc.
|
||||||||||
Recombinant Spermine Oxidase (SMOX) - RPC852Hu01 from Cloud-clone
|
||||||||||
Recombinant Human Spermine oxidase(SMOX) - CSB-YP021844HU CSB-EP021844HU CSB-BP021844HU CSB-MP021844HU from Cusabio
|
||||||||||
Spermine Oxidase Protein (Recombinant) - abx166466 from Abbexa
|
||||||||||
SMOX (transcript variant 2) - TP300156 from Acris Antibodies
|
||||||||||
SMOX Protein - NBP2-13356PEP from Novus Biologicals
|
||||||||||
SMO Peptide, Human - M34GP14764H from Creative Peptides
|
||||||||||
SMOX Peptide, Human - M34GP14767H from Creative Peptides
|
||||||||||
SMO Immunizing peptide - orb17588 from Biorbyt
|
||||||||||
Recombinant Spermine Oxidase (SMOX) - RPU51196 from Biomatik
|
||||||||||
SMOX Recombinant Protein (OPCD07076) - OPCD07076 from Aviva Systems Biology
|