| Gene Symbol | SMOX |
|---|---|
| Entrez Gene | 54498 |
| Alt Symbol | C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO |
| Species | Human |
| Gene Type | protein-coding |
| Description | spermine oxidase |
| Other Description | flavin containing amine oxidase|flavin-containing spermine oxidase|polyamine oxidase 1|putative cyclin G1 interacting protein |
| Swissprots | Q5TE26 Q9BW38 Q5TE27 D3DVZ4 Q9NPY1 Q9H6H1 Q8IX00 A2A2P5 Q96QT3 A2A2P6 Q6UY28 A8BE87 Q96LC4 Q9NWM0 Q9NP51 Q9NPY2 Q96LC3 |
| Accessions | EAX10457 EAX10458 EAX10459 EAX10460 EAX10461 EAX10462 EAX10463 Q9NWM0 AF519179 AAN77119 AK000753 BAA91360 AK025938 BAB15288 AK127286 AK293485 BAG56974 AL162058 CAB82396 AW136764 AY033889 AAK55763 AY033890 AAK55764 AY033891 AAK55765 AY358104 AAQ88471 BC000669 AAH00669 BG480614 BG679874 EF032141 ABM01872 U61836 XM_011529261 XP_011527563 NM_001270691 NP_001257620 NM_175839 NP_787033 NM_175840 NP_787034 NM_175841 NP_787035 NM_175842 NP_787036 |
| Function | Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal. |
| Subcellular Location | Isoform 6: Cytoplasm. Nucleus. |
| Tissue Specificity | Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO:0000269|PubMed:18422650}. |
| Top Pathways | Arginine and proline metabolism, beta-Alanine metabolism |
PAO CRISPR/Cas9 KO Plasmid (h) - sc-404683 from Santa Cruz Biotechnology
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PAO HDR Plasmid (h) - sc-404683-HDR from Santa Cruz Biotechnology
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PAO Double Nickase Plasmid (h) - sc-404683-NIC from Santa Cruz Biotechnology
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PAO Double Nickase Plasmid (h2) - sc-404683-NIC-2 from Santa Cruz Biotechnology
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PAO CRISPR Activation Plasmid (h) - sc-404683-ACT from Santa Cruz Biotechnology
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PAO CRISPR Activation Plasmid (h2) - sc-404683-ACT-2 from Santa Cruz Biotechnology
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PAO Lentiviral Activation Particles (h) - sc-404683-LAC from Santa Cruz Biotechnology
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PAO Lentiviral Activation Particles (h2) - sc-404683-LAC-2 from Santa Cruz Biotechnology
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PAO siRNA (h) - sc-44540 from Santa Cruz Biotechnology
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PAO shRNA Plasmid (h) - sc-44540-SH from Santa Cruz Biotechnology
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PAO shRNA (h) Lentiviral Particles - sc-44540-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU126461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19798 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19798 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12010 from Sigma-Aldrich
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SMOX siRNA (Human) - CRJ0096 from Cohesion Biosciences
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SMOX - MBS8229813 from MyBioSource
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shRNA set against Human SMOX (NM_175842.2) - SHH413544 from Creative biogene
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Human SMOX siRNA - orb270597 from Biorbyt
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SMOX shRNA Plasmid (Human) - CHJ0096 from Cohesion Biosciences
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SMOX miRNA 3'UTR clone - MiUTR3H-16136 from Creative biogene
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SMOX miRNA 3'UTR clone - MiUTR3H-16137 from Creative biogene
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SMOX miRNA 3'UTR clone - MiUTR3H-16138 from Creative biogene
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SMOX miRNA 3'UTR clone - MiUTR3H-16139 from Creative biogene
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