ORC2

Gene Symbol ORC2
Entrez Gene 4999
Alt Symbol ORC2L
Species Human
Gene Type protein-coding
Description origin recognition complex, subunit 2
Other Description origin recognition complex protein 2 homolog|origin recognition complex subunit 2|origin recognition complex, subunit 2 homolog
Swissprots Q13416 Q53TX5 Q13204
Accessions AAT46690 AAY14725 EAW70228 EAW70229 Q13416 AI033876 AK302614 BAG63861 AK316433 BAH14804 BC014834 AAH14834 BM470184 BP264347 CA448165 DA111542 DA545257 DQ894783 ABM85709 U27459 AAB33970 U40268 AAC50326 XM_006712555 XP_006712618 XM_011511252 XP_011509554 XM_011511253 XP_011509555 XM_011511254 XP_011509556 XR_427088 XR_922930 NM_006190 NP_006181 NR_033915
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin- mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Subcellular Location Nucleus.
Top Pathways Cell cycle

ORC2 (3G6) Rat mAb - 4736 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rat
Clonality Monoclonal
Clone 3G6
Western blot analysis of extracts from HeLa and HUVEC cells, using ORC2 (3G6) Rat mAb.

ORC2 (3G6) - sc-32734 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
ORC2 (3G6): sc-32734. Western blot analysis of ORC2 expression in U-2 OS whole cell lysate.

ORC2 (C-18) - sc-13238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ORC2 (C-18): sc-13238. Western blot analysis of ORC2 expression in non-transfected: sc-117752 (A) and human ORC2 transfected: sc-113531 (B) 293T whole cell lysates.

ORC2 (H-300) - sc-28742 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ORC2 (H-300): sc-28742. Western blot analysis of ORC2 expression in non-transfected: sc-117752 (A) and human ORC2 transfected: sc-113531 (B) 293T whole cell lysates.

Anti-ORC2 antibody - ab68348 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-ORC2 antibody (ab68348) at 1/500 dilution + Jurkat cell lysate at 25 µg/mlSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-ORC2 antibody - ab99277 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate carcinoma tissue labelling ORC2 with ab99277 at 1/1000 (0.2µg/mg). Detection: DAB.

Anti-ORC2 antibody - ab96249 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ORC2 antibody (ab96249) at 1/1000 dilution + Raji whole cell lysate at 30 µg

Anti-ORC2 antibody - ab123439 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ORC2 antibody (ab123439) at 1/100 dilution + Hela cell line lysate at 35 µg

Anti-ORC2 antibody [2ORC01 (same as 3F7/8)] - ab44956 from Abcam

Prices $370.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 2ORC01 (same as 3F7/8)

Anti-ORC2 antibody [3G6] - ab22537 from Abcam

Prices $372.00
Sizes 50 µl
Host Rat
Clonality Monoclonal
Clone 3G6

Anti-ORC2 antibody [SB46] - ab31930 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone SB46

Anti-ORC2 antibody - C-terminal - ab157562 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ORC2 antibody - C-terminal (ab157562) at 1 µg/ml + Mouse Lung lysate at 10 µg

Anti-ORC2L / ORC2 Antibody (aa208-479) - LS-C185535 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded CL1-0 Xenograft using ORC2 antibody at 1:100 dilution.

Anti-ORC2L / ORC2 Antibody (aa208-237) - LS-C163269 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ORC2L Antibody western blot of HUVEC cell line lysates (35 ug/lane). The ORC2L antibody detected the ORC2L protein (arrow).

Anti-ORC2L / ORC2 Antibody (aa1-50) - LS-C289457 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ORC2 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-ORC2 used at a dilution of 1:1000 (0.2 ug/mg).

Anti-ORC2L / ORC2 Antibody (aa150-200) - LS-C289456 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ORC2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-ORC2 used at a dilution of 1:200 (1 ug/mg).

Anti-ORC2L / ORC2 Antibody (clone 3B7) - LS-C179787 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3B7

Anti-ORC2L / ORC2 Antibody (clone 3E11-1G5) - LS-C133357 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E11-1G5
ORC2L monoclonal antibody (M01), clone 3E11-1G5 Western blot of ORC2L expression in Jurkat.

Anti-ORC2L / ORC2 Antibody - LS-C37898 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rat
Clonality Monoclonal

Anti-ORC2L / ORC2 Antibody (aa208-237, AP) - LS-C265223 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ORC2L / ORC2 Antibody (aa208-237, APC) - LS-C265224 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ORC2L / ORC2 Antibody (aa208-237, Biotin) - LS-C265225 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ORC2L / ORC2 Antibody (aa208-237, FITC) - LS-C265226 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ORC2L / ORC2 Antibody (aa208-237, Azide-free, HRP) - LS-C265227 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ORC2L / ORC2 Antibody (aa208-237, PE) - LS-C265228 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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