ORC2

Gene Symbol ORC2
Entrez Gene 4999
Alt Symbol ORC2L
Species Human
Gene Type protein-coding
Description origin recognition complex, subunit 2
Other Description origin recognition complex protein 2 homolog|origin recognition complex subunit 2|origin recognition complex, subunit 2 homolog
Swissprots Q13416 Q53TX5 Q13204
Accessions AAT46690 AAY14725 EAW70228 EAW70229 Q13416 AI033876 AK302614 BAG63861 AK316433 BAH14804 BC014834 AAH14834 BM470184 BP264347 CA448165 DA111542 DA545257 DQ894783 ABM85709 U27459 AAB33970 U40268 AAC50326 XM_006712555 XP_006712618 XM_011511252 XP_011509554 XM_011511253 XP_011509555 XM_011511254 XP_011509556 XR_427088 XR_922930 NM_006190 NP_006181 NR_033915
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin- mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Subcellular Location Nucleus.
Top Pathways Cell cycle

ORC2 CRISPR/Cas9 KO Plasmid (h) - sc-402746 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 HDR Plasmid (h) - sc-402746-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 Double Nickase Plasmid (h) - sc-402746-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 Double Nickase Plasmid (h2) - sc-402746-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 CRISPR Activation Plasmid (h) - sc-402746-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 CRISPR Activation Plasmid (h2) - sc-402746-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 Lentiviral Activation Particles (h) - sc-402746-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 Lentiviral Activation Particles (h2) - sc-402746-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ORC2 siRNA (h) - sc-38153 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ORC2 shRNA Plasmid (h) - sc-38153-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ORC2 shRNA (h) Lentiviral Particles - sc-38153-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057821 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16144 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16144 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ORC2 siRNA (Human) - CRH3317 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Orc2 RNAi - H00004999-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human ORC2 (NM_006190.4) - SHH368412 from Creative biogene

Category siRNA
Species Reactivities Human

Human ORC2 siRNA - orb263819 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ORC2 shRNA Plasmid (Human) - CHH3317 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ORC2 miRNA 3'UTR clone - MiUTR3H-03933 from Creative biogene

Species Reactivities Human
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