ORC2

Gene Symbol ORC2
Entrez Gene 4999
Alt Symbol ORC2L
Species Human
Gene Type protein-coding
Description origin recognition complex, subunit 2
Other Description origin recognition complex protein 2 homolog|origin recognition complex subunit 2|origin recognition complex, subunit 2 homolog
Swissprots Q13416 Q53TX5 Q13204
Accessions AAT46690 AAY14725 EAW70228 EAW70229 Q13416 AI033876 AK302614 BAG63861 AK316433 BAH14804 BC014834 AAH14834 BM470184 BP264347 CA448165 DA111542 DA545257 DQ894783 ABM85709 U27459 AAB33970 U40268 AAC50326 XM_006712555 XP_006712618 XM_011511252 XP_011509554 XM_011511253 XP_011509555 XM_011511254 XP_011509556 XR_427088 XR_922930 NM_006190 NP_006181 NR_033915
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin- mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
Subcellular Location Nucleus.
Top Pathways Cell cycle

Human ORC2 full length protein - ab132050 from Abcam

Category Protein
Source Wheat germ
Species Human
SDS-PAGE analysis of ab132050 on a 12.5% gel stained with Coomassie Blue.

Human ORC2 peptide - ab22896 from Abcam

Category Peptide
Species Human

ORC2L / ORC2 Antibody Blocking Peptide - LS-E3325 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

ORC2L / ORC2 Antibody Blocking Peptide - LS-E20608 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

ORC2L-Antibody-Center-Blocking-Peptide - BP14497c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

ORC2 - H00004999-P01-02 from Acris Antibodies

Category Protein
Prices $310.00
Sizes 2 µg
Source in vitro transl.
Species Human

ORC2L fusion protein - Ag3635 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, T-HIS
Species Human

Recombinant Human ORC2L, His-tagged - ORC2L-1466H from Creative Biomart

Category Protein
Source E.coli
Species Human

ORC2 Blocking Peptide - CBP2992 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat, Monkey

Recombinant Human Origin recognition complex subunit 2(ORC2) - CSB-YP614412HU CSB-EP614412HU CSB-BP614412HU CSB-MP614412HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

ORC2 - TP301599 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
ORC2

Origin recognition complex subunit 2 (ORC2), Recombinant Protein - MBS1396540 from MyBioSource

Category Protein
Prices $1,375.00, $1,375.00, $1,595.00, $1,595.00, $2,290.00, $2,290.00, $2,755.00, $2,755.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

ORC2 peptide - orb218855 from Biorbyt

Category Peptide
Species Human, Mouse
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