| Gene Symbol |
ORC2
|
| Entrez Gene |
4999
|
| Alt Symbol |
ORC2L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
origin recognition complex, subunit 2
|
| Other Description |
origin recognition complex protein 2 homolog|origin recognition complex subunit 2|origin recognition complex, subunit 2 homolog
|
| Swissprots |
Q13416 Q53TX5 Q13204
|
| Accessions |
AAT46690 AAY14725 EAW70228 EAW70229 Q13416 AI033876 AK302614 BAG63861 AK316433 BAH14804 BC014834 AAH14834 BM470184 BP264347 CA448165 DA111542 DA545257 DQ894783 ABM85709 U27459 AAB33970 U40268 AAC50326 XM_006712555 XP_006712618 XM_011511252 XP_011509554 XM_011511253 XP_011509555 XM_011511254 XP_011509556 XR_427088 XR_922930 NM_006190 NP_006181 NR_033915
|
| Function |
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin- mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Cell cycle
|
![Western Blot: Orc2 Overexpression Lysate (Adult Normal) [NBL1-13973] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Orc2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1646_Orc2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13973-img0002.jpg)