CDCA2

Gene Symbol CDCA2
Entrez Gene 157313
Alt Symbol PPP1R81, Repo-Man
Species Human
Gene Type protein-coding
Description cell division cycle associated 2
Other Description cell division cycle-associated protein 2|protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man|protein phosphatase 1, regulatory subunit 81|recruits PP1 onto mitotic chromatin at anaphase protein
Swissprots Q69YI4 Q4G0W0 Q69YH5 Q8N7C1 Q6P464 Q3SX74 Q5RKN0
Accessions Q69YH5 AK092164 BAG52490 AK098670 BAC05374 AK292505 BAF85194 AK299278 BAH12991 AL833396 CAH10585 AL833627 CAH10577 BC015691 BC036214 AAH36214 BC063651 AAH63651 BC085609 AAH85609 BC104450 AAI04451 BC104451 AAI04452 BG354575 BG716934 BM802460 BX649008 R95735 XM_005273418 XP_005273475 XM_006716294 XP_006716357 XM_011544415 XP_011542717 XM_011544416 XP_011542718 XM_011544417 XP_011542719 XM_011544418 XP_011542720 XM_011544419 XP_011542721 XM_011544420 XP_011542722 XR_949377 NM_152562 NP_689775
Function Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16492807}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:16492807}.

CDCA2 overexpression lysate - LY407470 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

CDCA2 Overexpression Lysate (Native) - NBP2-05350 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: CDCA2 Overexpression Lysate (Adult Normal) [NBP2-05350] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDCA2.
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