| Gene Symbol |
CDCA2
|
| Entrez Gene |
157313
|
| Alt Symbol |
PPP1R81, Repo-Man
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cell division cycle associated 2
|
| Other Description |
cell division cycle-associated protein 2|protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man|protein phosphatase 1, regulatory subunit 81|recruits PP1 onto mitotic chromatin at anaphase protein
|
| Swissprots |
Q69YI4 Q4G0W0 Q69YH5 Q8N7C1 Q6P464 Q3SX74 Q5RKN0
|
| Accessions |
Q69YH5 AK092164 BAG52490 AK098670 BAC05374 AK292505 BAF85194 AK299278 BAH12991 AL833396 CAH10585 AL833627 CAH10577 BC015691 BC036214 AAH36214 BC063651 AAH63651 BC085609 AAH85609 BC104450 AAI04451 BC104451 AAI04452 BG354575 BG716934 BM802460 BX649008 R95735 XM_005273418 XP_005273475 XM_006716294 XP_006716357 XM_011544415 XP_011542717 XM_011544416 XP_011542718 XM_011544417 XP_011542719 XM_011544418 XP_011542720 XM_011544419 XP_011542721 XM_011544420 XP_011542722 XR_949377 NM_152562 NP_689775
|
| Function |
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16492807}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:16492807}.
|
