| Gene Symbol | CDCA2 |
|---|---|
| Entrez Gene | 157313 |
| Alt Symbol | PPP1R81, Repo-Man |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle associated 2 |
| Other Description | cell division cycle-associated protein 2|protein phosphatase 1 [gamma] (PPP1R3A) binding protein Repo-Man|protein phosphatase 1, regulatory subunit 81|recruits PP1 onto mitotic chromatin at anaphase protein |
| Swissprots | Q69YI4 Q4G0W0 Q69YH5 Q8N7C1 Q6P464 Q3SX74 Q5RKN0 |
| Accessions | Q69YH5 AK092164 BAG52490 AK098670 BAC05374 AK292505 BAF85194 AK299278 BAH12991 AL833396 CAH10585 AL833627 CAH10577 BC015691 BC036214 AAH36214 BC063651 AAH63651 BC085609 AAH85609 BC104450 AAI04451 BC104451 AAI04452 BG354575 BG716934 BM802460 BX649008 R95735 XM_005273418 XP_005273475 XM_006716294 XP_006716357 XM_011544415 XP_011542717 XM_011544416 XP_011542718 XM_011544417 XP_011542719 XM_011544418 XP_011542720 XM_011544419 XP_011542721 XM_011544420 XP_011542722 XR_949377 NM_152562 NP_689775 |
| Function | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16492807}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:16492807}. |
Repo-Man CRISPR/Cas9 KO Plasmid (h) - sc-405105 from Santa Cruz Biotechnology
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Repo-Man HDR Plasmid (h) - sc-405105-HDR from Santa Cruz Biotechnology
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Repo-Man Double Nickase Plasmid (h) - sc-405105-NIC from Santa Cruz Biotechnology
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Repo-Man Double Nickase Plasmid (h2) - sc-405105-NIC-2 from Santa Cruz Biotechnology
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Repo-Man CRISPR Activation Plasmid (h) - sc-405105-ACT from Santa Cruz Biotechnology
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Repo-Man CRISPR Activation Plasmid (h2) - sc-405105-ACT-2 from Santa Cruz Biotechnology
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Repo-Man Lentiviral Activation Particles (h) - sc-405105-LAC from Santa Cruz Biotechnology
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Repo-Man Lentiviral Activation Particles (h2) - sc-405105-LAC-2 from Santa Cruz Biotechnology
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Repo-Man siRNA (h) - sc-76388 from Santa Cruz Biotechnology
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Repo-Man shRNA Plasmid (h) - sc-76388-SH from Santa Cruz Biotechnology
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Repo-Man shRNA (h) Lentiviral Particles - sc-76388-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5798 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5798 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00480 from Sigma-Aldrich
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CDCA2 siRNA (Human) - CRJ5821 from Cohesion Biosciences
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CDCA2 - MBS8201612 from MyBioSource
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shRNA set against Human CDCA2 (NM_152562.2) - SHH260001 from Creative biogene
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shRNA set against Human CDCA2(NM_152562.2) - SHG162217 from Creative biogene
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Human CDCA2 siRNA - orb276322 from Biorbyt
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CDCA2 shRNA Plasmid (Human) - CHJ5821 from Cohesion Biosciences
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CDCA2 miRNA 3'UTR clone - MiUTR1H-01965 from Creative biogene
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