KSR2

Gene Symbol	KSR2
Entrez Gene	283455
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	kinase suppressor of ras 2
Other Description	kinase suppressor of Ras 2
Swissprots	A0PJT2 Q6VAB6 Q8N775 Q3B828
Accessions	CAH68720 EAW98111 EAW98112 Q6VAB6 AK098831 BAC05426 AY345972 AAQ24226 BC107106 AAI07107 BC107107 AAI07108 BC127603 AAI27604 BX648958 DW009880 DW009881 XM_011538224 XP_011536526 XM_011538225 XP_011536527 XM_011538226 XP_011536528 XM_011538227 XP_011536529 XM_011538228 XP_011536530 XM_011538229 XP_011536531 XM_011538230 XP_011536532 XR_944522 NM_173598 NP_775869
Function	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. {ECO:0000269|PubMed:12975377, ECO:0000269|PubMed:16039990, ECO:0000269|PubMed:21441910}.
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Mainly expressed in brain and kidney. {ECO:0000269|PubMed:12975377}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KSR2 - MBS1266235 from MyBioSource Species Human Accession BC127603

Human KSR2 cDNA clone(NM_173598.4) - CDFG010897 from Creative Biomart Species Human Accession NM_173598.4

Human KSR2 ORF Clone(NM_173598.4) - CDCR322091 from Creative Biomart Species Human Accession NM_173598.4

Human KSR2 ORF Clone(NM_173598.4) - CDCR322092 from Creative Biomart Species Human Accession NM_173598.4

Human KSR2 Gene ORF cDNA clone in cloning vector - HG15990-G from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, N-His tag - HG15990-NH from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, C-His tag - HG15990-CH from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15990-NF from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid - HG15990-UT from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15990-CF from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15990-NM from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15990-CM from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15990-CY from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15990-ACG from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15990-ANG from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15990-ACR from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15990-ANR from Sino Biological Species Human

Human KSR2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15990-NY from Sino Biological Species Human

Human KSR2 ORF clone (NM_173598.4) - CDCL125917 from Creative biogene Species Human

Human KSR2 ORF Clone (BC127603) - CDCS417433 from Creative biogene Species Human Accession Q6VAB6

Human KSR2 ORF clone (BC127603) - CDCB157591 from Creative biogene Species Human

Human KSR2 Gene cDNA Clone - orb144021 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human KSR2 cDNA Clone(NM_173598.4) - CDFG010897 from Creative biogene Species Human

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