KSR2

Gene Symbol	KSR2
Entrez Gene	283455
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	kinase suppressor of ras 2
Other Description	kinase suppressor of Ras 2
Swissprots	A0PJT2 Q6VAB6 Q8N775 Q3B828
Accessions	CAH68720 EAW98111 EAW98112 Q6VAB6 AK098831 BAC05426 AY345972 AAQ24226 BC107106 AAI07107 BC107107 AAI07108 BC127603 AAI27604 BX648958 DW009880 DW009881 XM_011538224 XP_011536526 XM_011538225 XP_011536527 XM_011538226 XP_011536528 XM_011538227 XP_011536529 XM_011538228 XP_011536530 XM_011538229 XP_011536531 XM_011538230 XP_011536532 XR_944522 NM_173598 NP_775869
Function	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8- mediated signaling. Acts as a negative regulator of MAP3K3- mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. {ECO:0000269|PubMed:12975377, ECO:0000269|PubMed:16039990, ECO:0000269|PubMed:21441910}.
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity	Mainly expressed in brain and kidney. {ECO:0000269|PubMed:12975377}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ksr-2 CRISPR/Cas9 KO Plasmid (h) - sc-402872 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 HDR Plasmid (h) - sc-402872-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 Double Nickase Plasmid (h) - sc-402872-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 Double Nickase Plasmid (h2) - sc-402872-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 CRISPR Activation Plasmid (h) - sc-402872-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 CRISPR Activation Plasmid (h2) - sc-402872-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 Lentiviral Activation Particles (h) - sc-402872-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 Lentiviral Activation Particles (h2) - sc-402872-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ksr-2 siRNA (h) - sc-60901 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ksr-2 shRNA Plasmid (h) - sc-60901-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Ksr-2 shRNA (h) Lentiviral Particles - sc-60901-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

KSR2 RNAi - H00283455-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU141441 from Sigma-Aldrich Category siRNA

MISSION® siRNA - SIHK1037 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1036 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1038 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN11505 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11505 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

KSR2 siRNA (Human) - CRJ6906 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

KSR2 RNAi - H00283455-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human KSR2 (NM_173598.4) - SHH327919 from Creative biogene Category siRNA Species Reactivities Human

Human KSR2 siRNA - orb277407 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

KSR2 shRNA Plasmid (Human) - CHJ6906 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

KSR2 miRNA 3'UTR clone - MiUTR1H-05540 from Creative biogene Species Reactivities Human

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