| Gene Symbol |
SRPX2
|
| Entrez Gene |
27286
|
| Alt Symbol |
BPP, CBPS, PMGX, RESDX, SRPUL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sushi-repeat containing protein, X-linked 2
|
| Other Description |
sushi repeat-containing protein SRPX2|sushi-repeat protein up-regulated in leukemia|sushi-repeat protein upregulated in leukemia|sushi-repeat-containing protein, X-linked 2
|
| Swissprots |
O60687 B3KQT3 Q8WW85
|
| Accessions |
EAX02812 O60687 AF060567 AAC15765 AF393649 AAM73693 AK075462 BAG52145 AU104738 BC020733 AAH20733 BP279501 BU625416 BX339682 DA707631 XM_005262121 XP_005262178 NM_014467 NP_055282
|
| Function |
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:24179158}.
|
| Subcellular Location |
Secreted. Cytoplasm. Cell surface. Cell junction, synapse {ECO:0000250}.
|
| Tissue Specificity |
Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa. {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:22242148, ECO:0000269|PubMed:9864177}.
|