SRPX2
| Gene Symbol | SRPX2 |
|---|---|
| Entrez Gene | 27286 |
| Alt Symbol | BPP, CBPS, PMGX, RESDX, SRPUL |
| Species | Human |
| Gene Type | protein-coding |
| Description | sushi-repeat containing protein, X-linked 2 |
| Other Description | sushi repeat-containing protein SRPX2|sushi-repeat protein up-regulated in leukemia|sushi-repeat protein upregulated in leukemia|sushi-repeat-containing protein, X-linked 2 |
| Swissprots | O60687 B3KQT3 Q8WW85 |
| Accessions | EAX02812 O60687 AF060567 AAC15765 AF393649 AAM73693 AK075462 BAG52145 AU104738 BC020733 AAH20733 BP279501 BU625416 BX339682 DA707631 XM_005262121 XP_005262178 NM_014467 NP_055282 |
| Function | Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:24179158}. |
| Subcellular Location | Secreted. Cytoplasm. Cell surface. Cell junction, synapse {ECO:0000250}. |
| Tissue Specificity | Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed in numerous cancer cell lines and in gastrointestinal cancer cells. Higher levels found in colorectal cancers than in normal colonic mucosa. {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:22242148, ECO:0000269|PubMed:9864177}. |
Human SRPX2 full length protein - ab132897 from Abcam
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SRPX2 peptide - ab101235 from Abcam
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SRPX2 Antibody Blocking Peptide - LS-E30809 from LifeSpan Bioscience
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SRPX2 Antibody Blocking Peptide - LS-E29620 from LifeSpan Bioscience
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SRPX2 Antibody Blocking Peptide - LS-E29621 from LifeSpan Bioscience
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SRPX2 Antibody Blocking Peptide - LS-E29811 from LifeSpan Bioscience
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Recombinant Human SRPX2 Protein - H00027286-P01 from Novus Biologicals
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SRPX2 Blocking Peptide - NBP1-77370PEP from Novus Biologicals
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SRPX2 / SRPUL - H00027286-P01-10 from Acris Antibodies
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SRPX2 / SRPUL - H00027286-P01-25 from Acris Antibodies
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SRPX2 / SRPUL Control Peptide - AP30828CP-N from Acris Antibodies
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SRPX2 Peptide - 5475P from ProSci
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SRPX2 fusion protein - ag8084 from Proteintech Group
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SRPX2 fusion protein - ag2516 from Proteintech Group
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Recombinant Human SRPX2, His-tagged - SRPX2-2960H from Creative Biomart
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Recombinant Human Sushi repeat-containing protein SRPX2(SRPX2) - CSB-YP022690HU CSB-EP022690HU CSB-BP022690HU CSB-MP022690HU from Cusabio
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SRPX2 Recombinant Protein Antigen - NBP1-86999PEP from Novus Biologicals
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SRPX2-Antibody-Center-Blocking-peptide - BP5277c from Abgent, a WuXi AppTec company
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SRPX2 Peptide, Human - M34GP15167H from Creative Peptides
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Sushi repeat-containing protein SRPX2 (SRPX2), Recombinant Protein - MBS1025409 from MyBioSource
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