SIRT7

Gene Symbol SIRT7
Entrez Gene 51547
Alt Symbol SIR2L7
Species Human
Gene Type protein-coding
Description sirtuin 7
Other Description NAD-dependent deacetylase sirtuin-7|NAD-dependent protein deacetylase sirtuin-7|SIR2-like protein 7|regulatory protein SIR2 homolog 7|silent mating type information regulation 2, S.cerevisiae, homolog 7|sir2-related protein type 7|sirtuin type 7
Swissprots B3KSU8 A8K2K0 Q9NUS6 Q3MIK4 Q9NRC8 Q9NSZ6
Accessions CAL00162 CAL48204 CAN36298 EAW89713 Q9NRC8 AF233395 AAF43431 AK002027 BAA92044 AK094326 BAG52860 AK131437 AK131484 AK290265 BAF82954 AL137626 CAB70848 BC017305 AAH17305 BC101791 AAI01792 BC101793 AAI01794 BQ890203 CD579273 DQ892354 ABM83280 DQ895561 ABM86487 XM_006722284 XP_006722347 XM_011523580 XP_011521882 XM_011523581 XP_011521883 XR_430032 XR_933936 NM_016538 NP_057622
Function NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transc
Subcellular Location Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

SirT7 (D3K5A) Rabbit mAb - 5360 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3K5A
Western blot analysis of extracts from various cell lines using SirT7 (D3K5A) Rabbit mAb.

SIRT7 (C-3) - sc-365344 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIRT7 (C-3): sc-365344. Western blot analysis of SIRT7 expression in Caki-1 (A), HeLa (B) and K-562 (C) whole cell lysates.

SIRT7 (G-20) - sc-66281 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIRT7 (G-20): sc-66281. Western blot analysis of SIRT7 expression in non-transfected: sc-117752 (A) and human SIRT7 transfected: sc-173921 (B) 293T whole cell lysates.

SIRT7 (H-105) - sc-135055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SIRT7 (H-105): sc-135055. Western blot analysis of SIRT7 expression in NIH/3T3 nuclear extract.

SIRT7 (P-15) - sc-66283 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIRT7 (P-15): sc-66283. Western blot analysis of SIRT7 expression in non-transfected: sc-117752 (A) and human SIRT7 transfected: sc-173921 (B) 293T whole cell lysates.

Anti-SIRT7 antibody - ab135567 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIRT7 antibody (ab135567) at 1/100 dilutionLane 1 : Lysate of non transfected HEK293 cellsLane 2 : Lysate of HEK293 cells transiently transfected with the SIRT7 gene.Lysates/proteins at 2 µg per lane.

Anti-SIRT7 antibody - ab13682 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 antibody - C-terminal - ab176369 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIRT7 antibody - C-terminal (ab176369) at 1/1000 dilutionLane 1 : Jurkat total cell extractLane 2 : HeLa total cell extract

Anti-SIRT7 / Sirtuin 7 Antibody (aa317-366) IHC-plus™ - LS-B1566 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT7 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1566 concentration 5 ug/ml.

Anti-SIRT7 / Sirtuin 7 Antibody IHC-plus™ - LS-B2061 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT7 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2061 concentration 5 ug/ml.

Anti-SIRT7 / Sirtuin 7 Antibody (aa331-360) IHC-plus™ - LS-B6912 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SIRT7 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6912 concentration 10 ug/ml.

Anti-SIRT7 / Sirtuin 7 Antibody - LS-C331178 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat kidney using SIRT7 antibody at dilution of 1:100 (200x lens).

Anti-SIRT7 / Sirtuin 7 Antibody (aa346-361) - LS-C3193 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (N-Terminus) - LS-C10187 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-SIRT7 / Sirtuin 7 Antibody - LS-C153160 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (C-Terminus, APC) - LS-C226352 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (C-Terminus, AP) - LS-C226350 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (C-Terminus, Biotin) - LS-C226353 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (Internal) - LS-C141851 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of SIRT7 in human liver lysates.

Anti-SIRT7 / Sirtuin 7 Antibody (C-Terminus, FITC) - LS-C226354 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (C-Terminus, Azide-free, HRP) - LS-C226355 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (C-Terminus) - LS-C109658 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SIRT7 antibody LS-C109658 Western blot of SH-SYSY lysate.

Anti-SIRT7 / Sirtuin 7 Antibody (Internal) - LS-C141854 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
SIRT7 Immunoprecipitated from human liver lysates with SIRT7 Antibody LS-C141854. A). SIRT7 Antibody LS-C141851 B). SIRT7 Antibody LS-C141850

Anti-SIRT7 / Sirtuin 7 Antibody (C-Terminus, PE) - LS-C226356 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIRT7 / Sirtuin 7 Antibody (Internal) - LS-C141850 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of SIRT7 in human liver lysates.
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