| Gene Symbol |
SIRT7
|
| Entrez Gene |
51547
|
| Alt Symbol |
SIR2L7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sirtuin 7
|
| Other Description |
NAD-dependent deacetylase sirtuin-7|NAD-dependent protein deacetylase sirtuin-7|SIR2-like protein 7|regulatory protein SIR2 homolog 7|silent mating type information regulation 2, S.cerevisiae, homolog 7|sir2-related protein type 7|sirtuin type 7
|
| Swissprots |
B3KSU8 A8K2K0 Q9NUS6 Q3MIK4 Q9NRC8 Q9NSZ6
|
| Accessions |
CAL00162 CAL48204 CAN36298 EAW89713 Q9NRC8 AF233395 AAF43431 AK002027 BAA92044 AK094326 BAG52860 AK131437 AK131484 AK290265 BAF82954 AL137626 CAB70848 BC017305 AAH17305 BC101791 AAI01792 BC101793 AAI01794 BQ890203 CD579273 DQ892354 ABM83280 DQ895561 ABM86487 XM_006722284 XP_006722347 XM_011523580 XP_011521882 XM_011523581 XP_011521883 XR_430032 XR_933936 NM_016538 NP_057622
|
| Function |
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transc
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
|