SIRT7

Gene Symbol	SIRT7
Entrez Gene	51547
Alt Symbol	SIR2L7
Species	Human
Gene Type	protein-coding
Description	sirtuin 7
Other Description	NAD-dependent deacetylase sirtuin-7|NAD-dependent protein deacetylase sirtuin-7|SIR2-like protein 7|regulatory protein SIR2 homolog 7|silent mating type information regulation 2, S.cerevisiae, homolog 7|sir2-related protein type 7|sirtuin type 7
Swissprots	B3KSU8 A8K2K0 Q9NUS6 Q3MIK4 Q9NRC8 Q9NSZ6
Accessions	CAL00162 CAL48204 CAN36298 EAW89713 Q9NRC8 AF233395 AAF43431 AK002027 BAA92044 AK094326 BAG52860 AK131437 AK131484 AK290265 BAF82954 AL137626 CAB70848 BC017305 AAH17305 BC101791 AAI01792 BC101793 AAI01794 BQ890203 CD579273 DQ892354 ABM83280 DQ895561 ABM86487 XM_006722284 XP_006722347 XM_011523580 XP_011521882 XM_011523581 XP_011521883 XR_430032 XR_933936 NM_016538 NP_057622
Function	NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transc
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SIRT7 full length protein - ab104032 from Abcam Category Protein Prices $302.00, $410.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human SIRT7 full length protein - ab109045 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source E. coli Species Human

Human SIRT7 full length protein - ab95246 from Abcam Category Protein Source E. coli Species Human

Human SIRT7 protein fragment - ab176933 from Abcam Category Protein Source E. coli Species Human

SIRT7 / Sirtuin 7 Antibody Blocking Peptide - LS-E8150 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT7 / Sirtuin 7 Antibody Blocking Peptide - LS-E30937 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

SIRT7 / Sirtuin 7 Antibody Blocking Peptide - LS-E11348 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIRT7 / Sirtuin 7 Antibody Blocking Peptide - LS-E11349 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SIRT7 Protein - H00051547-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SIRT7 Protein - H00051547-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SIRT7 Peptide - NBP1-76268PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

SIRT7 Peptide - P1851 from Novus Biologicals Category Peptide Species Human

SIRT7-Antibody-C-term-Blocking-Peptide - BP6246a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIRT7 Peptide - GTX85103-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

SIRT7 Blocking Peptide - 33R-2220 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIRT7 Blocking Peptide - 33R-3223 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIRT7 Blocking Peptide - 33R-10633 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

SIRT7 - H00051547-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SIRT7 - H00051547-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SIRT7 - H00051547-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SIRT7 control peptide - AP26215CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SIRT7 Peptide - 5775P from ProSci Category Peptide Species Human

SIRT7 fusion protein - ag3656 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Sirtuin 7, Active Human Recombinant Protein - GWB-CCF2E4 from Genway Biotech Category Protein Prices $566.00 Sizes 100 µg Species Human

Recombinant Human SIRT7, His-tagged - SIRT7-585H from Creative Biomart Category Protein Source E.coli.

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