Gene Symbol | SRSF6 |
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Entrez Gene | 6431 |
Alt Symbol | B52, HEL-S-91, SFRS6, SRP55 |
Species | Human |
Gene Type | protein-coding |
Description | serine/arginine-rich splicing factor 6 |
Other Description | SR splicing factor 6|epididymis secretory protein Li 91|pre-mRNA-splicing factor SRP55|splicing factor, arginine/serine-rich, 55 kDa |
Swissprots | Q9UJB8 Q13247 Q13244 Q13245 Q96J06 B7Z6J3 E1P5W6 Q9Y3N7 |
Accessions | EAW75964 EAW75965 EAW75966 EAW75967 Q13247 AB208976 BAD92213 AB451251 BAG70065 AB451375 BAG70189 AK123171 AK291203 BAF83892 AK300411 BAH13279 AL110214 AV704620 BC006832 AAH06832 BM788391 BM830876 DC306805 EU668347 ACF94500 U30828 AAA93071 U30883 AAA93073 XR_936608 NM_006275 NP_006266 NR_034009 |
Function | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269|PubMed:12549914, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:22767602, ECO:0000269|PubMed:24440982}. |
Subcellular Location | Nucleus. Nucleus speckle. |
Top Pathways | Spliceosome, Herpes simplex infection |
SRp55 CRISPR/Cas9 KO Plasmid (h) - sc-401621 from Santa Cruz Biotechnology
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SRp55 HDR Plasmid (h) - sc-401621-HDR from Santa Cruz Biotechnology
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SRp55 Double Nickase Plasmid (h) - sc-401621-NIC from Santa Cruz Biotechnology
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SRp55 Double Nickase Plasmid (h2) - sc-401621-NIC-2 from Santa Cruz Biotechnology
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SRp55 CRISPR Activation Plasmid (h) - sc-401621-ACT from Santa Cruz Biotechnology
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SRp55 CRISPR Activation Plasmid (h2) - sc-401621-ACT-2 from Santa Cruz Biotechnology
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SRp55 Lentiviral Activation Particles (h) - sc-401621-LAC from Santa Cruz Biotechnology
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SRp55 Lentiviral Activation Particles (h2) - sc-401621-LAC-2 from Santa Cruz Biotechnology
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SRp55 siRNA (h) - sc-44118 from Santa Cruz Biotechnology
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SRp55 shRNA Plasmid (h) - sc-44118-SH from Santa Cruz Biotechnology
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SRp55 shRNA (h) Lentiviral Particles - sc-44118-V from Santa Cruz Biotechnology
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SRp55 RNAi - H00006431-R01 from Novus Biologicals
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MISSION® esiRNA - EHU113551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20605 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20605 from Sigma-Aldrich
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SRSF6 siRNA (Human) - CRH4346 from Cohesion Biosciences
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SRSF6 - MBS828775 from MyBioSource
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Human SRSF6 siRNA - orb264848 from Biorbyt
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SRSF6 shRNA Plasmid (Human) - CHH4346 from Cohesion Biosciences
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SRSF6 miRNA 3'UTR clone - MiUTR4H-TG08545 from Creative biogene
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