| Gene Symbol |
MAD2L1
|
| Entrez Gene |
4085
|
| Alt Symbol |
HSMAD2, MAD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MAD2 mitotic arrest deficient-like 1 (yeast)
|
| Other Description |
MAD2 (mitotic arrest deficient, yeast, homolog)-like 1|MAD2-like protein 1|mitotic arrest deficient 2-like protein 1|mitotic arrest deficient, yeast, homolog-like 1|mitotic spindle assembly checkpoint protein MAD2A
|
| Swissprots |
Q6IRW7 Q548X9 Q53F56 Q13257 Q8IZX3
|
| Accessions |
AAK38174 AAY40945 BAB63410 EAX05270 EAX05271 EAX05273 Q13257 AA443733 AF394735 AAN74648 AJ000186 CAA03943 AK223433 BAD97153 AK298228 BAG60497 AK313827 BAG36562 BC000356 AAH00356 BC005945 AAH05945 BC070283 AAH70283 EU831987 ACE87428 EU832080 ACE86742 NM_002358 NP_002349
|
| Function |
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. {ECO:0000269|PubMed:10700282, ECO:0000269|PubMed:11804586, ECO:0000269|PubMed:15024386}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. {ECO:0000305}.
|
| Top Pathways |
Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection
|