MAD2L1

Gene Symbol	MAD2L1
Entrez Gene	4085
Alt Symbol	HSMAD2, MAD2
Species	Human
Gene Type	protein-coding
Description	MAD2 mitotic arrest deficient-like 1 (yeast)
Other Description	MAD2 (mitotic arrest deficient, yeast, homolog)-like 1|MAD2-like protein 1|mitotic arrest deficient 2-like protein 1|mitotic arrest deficient, yeast, homolog-like 1|mitotic spindle assembly checkpoint protein MAD2A
Swissprots	Q6IRW7 Q548X9 Q53F56 Q13257 Q8IZX3
Accessions	AAK38174 AAY40945 BAB63410 EAX05270 EAX05271 EAX05273 Q13257 AA443733 AF394735 AAN74648 AJ000186 CAA03943 AK223433 BAD97153 AK298228 BAG60497 AK313827 BAG36562 BC000356 AAH00356 BC005945 AAH05945 BC070283 AAH70283 EU831987 ACE87428 EU832080 ACE86742 NM_002358 NP_002349
Function	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. {ECO:0000269|PubMed:10700282, ECO:0000269|PubMed:11804586, ECO:0000269|PubMed:15024386}.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. {ECO:0000305}.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAD2 peptide - ab61590 from Abcam Category Peptide

Human Mad2L1 full length protein - ab113604 from Abcam Category Protein Source E. coli Species Human

MAD2L1 / MAD2 Antibody Blocking Peptide - LS-E10518 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAD2L1 / MAD2 Antibody Blocking Peptide - LS-E25421 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAD2L1 Recombinant Protein - H00004085-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MAD2L1 Peptide - NBP1-96765 from Novus Biologicals Category Peptide Prices $169.00 Sizes 50 µg

Recombinant Human MAD2L1 Protein - NBP1-72458 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 10 µg, 50 µg Source E. coli Species Human

MAD2L1-Antibody-Center-Blocking-peptide - BP13837c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human MAD2L1 His tag protein - orb84567 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Human MAD2L1 protein - orb246556 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human MAD2L1 protein - orb168761 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Source E. coli

MAD2L1 Blocking Peptide - 33R-6124 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAD2L1 protein (His tag) - 80R-1972 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

MAD2L1 Peptide - AC21-0249-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MAD2L1 (1-205, His-tag) - AR50041PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

MAD2L1 (1-205, His-tag) - AR50041PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

MAD2L1 - H00004085-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAD2L1 - H00004085-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAD2L1 Control Peptide - R1540CP from Acris Antibodies Category Peptide Prices $109.00 Sizes 50 µg

MAD2L1, 1-205aa, Human, His tag, E.coli - 01-P1216 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

MAD2L1 Peptide - 45-853P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

MAD2 Recombinant Protein - 96-529 from ProSci Category Protein Prices $450.00 Sizes 100 µg Source E. coli Species Human

MAD2L1 fusion protein - Ag0307 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MAD2L1 fusion protein - Ag17512 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human MAD2L1 Protein - BP001769-PRO-934 from Syd Labs Category Protein Prices $160.00, $1,100.00 Sizes 5 µg, 50 µg Source Escherichia Coli-derived. Species Human

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