MAD2L1

Gene Symbol MAD2L1
Entrez Gene 4085
Alt Symbol HSMAD2, MAD2
Species Human
Gene Type protein-coding
Description MAD2 mitotic arrest deficient-like 1 (yeast)
Other Description MAD2 (mitotic arrest deficient, yeast, homolog)-like 1|MAD2-like protein 1|mitotic arrest deficient 2-like protein 1|mitotic arrest deficient, yeast, homolog-like 1|mitotic spindle assembly checkpoint protein MAD2A
Swissprots Q6IRW7 Q548X9 Q53F56 Q13257 Q8IZX3
Accessions AAK38174 AAY40945 BAB63410 EAX05270 EAX05271 EAX05273 Q13257 AA443733 AF394735 AAN74648 AJ000186 CAA03943 AK223433 BAD97153 AK298228 BAG60497 AK313827 BAG36562 BC000356 AAH00356 BC005945 AAH05945 BC070283 AAH70283 EU831987 ACE87428 EU832080 ACE86742 NM_002358 NP_002349
Function Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. {ECO:0000269|PubMed:10700282, ECO:0000269|PubMed:11804586, ECO:0000269|PubMed:15024386}.
Subcellular Location Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD. {ECO:0000305}.
Top Pathways Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, HTLV-I infection

MAD2 CRISPR/Cas9 KO Plasmid (h) - sc-401027 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 HDR Plasmid (h) - sc-401027-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 Double Nickase Plasmid (h) - sc-401027-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 Double Nickase Plasmid (h2) - sc-401027-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 CRISPR Activation Plasmid (h) - sc-401027-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 CRISPR Activation Plasmid (h2) - sc-401027-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 Lentiviral Activation Particles (h) - sc-401027-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 Lentiviral Activation Particles (h2) - sc-401027-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAD2 siRNA (h) - sc-35837 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAD2 shRNA Plasmid (h) - sc-35837-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAD2 shRNA (h) Lentiviral Particles - sc-35837-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU074611 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12893 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12893 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05695 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05695

MAD2L1 siRNA (Human) - CRH2768 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MAD2L1 RNAi - H00004085-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MAD2L1 (NM_002358.3) - SHH336519 from Creative biogene

Category siRNA
Species Reactivities Human

MAD2L1 shRNA Plasmid (Human) - CHH2768 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAD2L1 miRNA 3'UTR clone - MiUTR3H-04136 from Creative biogene

Species Reactivities Human
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