| Gene Symbol |
NMNAT3
|
| Entrez Gene |
349565
|
| Alt Symbol |
FKSG76, PNAT-3, PNAT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nicotinamide nucleotide adenylyltransferase 3
|
| Other Description |
NMN adenylyltransferase 3|NMN/NaMN adenylyltransferase 3|NaMN adenylyltransferase 3|nicotinamide mononucleotide adenylyltransferase 3|nicotinamide-nucleotide adenylyltransferase 3|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3|nicotinate-nucleotide adenylyltransferase 3|pyridine nucleotide adenylyltransferase 3
|
| Swissprots |
D3DNF2 B3KVR6 D3DNF3 Q96T66 Q8N4G1
|
| Accessions |
EAW79022 EAW79023 EAW79024 EAW79025 EAW79026 EAW79027 EAW79028 EAW79029 EAW79030 EAW79031 EAW79032 EAW79033 Q96T66 AA894638 AF345564 AAK52726 AK123208 BAG53878 AK127477 BAG54510 BC034374 AAH34374 BC036218 AAH36218 BX649063 DB454216 DQ890804 ABM81730 DQ893959 ABM84885 XM_006713624 XP_006713687 XM_006713628 XP_006713691 XM_006713629 XP_006713692 XM_011512790 XP_011511092 XM_011512791 XP_011511093 XM_011512792 XP_011511094 XM_011512793 XP_011511095 NM_001200047 NP_001186976 NM_178177 NP_835471
|
| Function |
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.
|
| Subcellular Location |
Mitochondrion {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
|
| Tissue Specificity |
Expressed in lung and spleen with lower levels in placenta and kidney. {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
|
| Top Pathways |
Nicotinate and nicotinamide metabolism
|