NMNAT3

Gene Symbol	NMNAT3
Entrez Gene	349565
Alt Symbol	FKSG76, PNAT-3, PNAT3
Species	Human
Gene Type	protein-coding
Description	nicotinamide nucleotide adenylyltransferase 3
Other Description	NMN adenylyltransferase 3|NMN/NaMN adenylyltransferase 3|NaMN adenylyltransferase 3|nicotinamide mononucleotide adenylyltransferase 3|nicotinamide-nucleotide adenylyltransferase 3|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3|nicotinate-nucleotide adenylyltransferase 3|pyridine nucleotide adenylyltransferase 3
Swissprots	D3DNF2 B3KVR6 D3DNF3 Q96T66 Q8N4G1
Accessions	EAW79022 EAW79023 EAW79024 EAW79025 EAW79026 EAW79027 EAW79028 EAW79029 EAW79030 EAW79031 EAW79032 EAW79033 Q96T66 AA894638 AF345564 AAK52726 AK123208 BAG53878 AK127477 BAG54510 BC034374 AAH34374 BC036218 AAH36218 BX649063 DB454216 DQ890804 ABM81730 DQ893959 ABM84885 XM_006713624 XP_006713687 XM_006713628 XP_006713691 XM_006713629 XP_006713692 XM_011512790 XP_011511092 XM_011512791 XP_011511093 XM_011512792 XP_011511094 XM_011512793 XP_011511095 NM_001200047 NP_001186976 NM_178177 NP_835471
Function	Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
Tissue Specificity	Expressed in lung and spleen with lower levels in placenta and kidney. {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
Top Pathways	Nicotinate and nicotinamide metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human NMNAT3 full length protein - ab157274 from Abcam Category Protein Prices $588.00 Sizes 100 µg Source E. coli Species Human

Human NMNAT3 full length protein - ab153644 from Abcam Category Protein Source Wheat germ Species Human

Human NMNAT3 protein fragment - ab153645 from Abcam Category Protein Source Wheat germ Species Human

NMNAT3 peptide - ab185635 from Abcam Category Peptide

NMNAT3 Antibody Blocking Peptide - LS-E2958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMNAT3 Antibody Blocking Peptide - LS-E27730 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMNAT3 Antibody Blocking Peptide - LS-E27731 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMNAT3 Antibody Blocking Peptide - LS-E17777 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMNAT3 Antibody Blocking Peptide - LS-E26690 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human NMNAT3 Protein - H00349565-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human NMNAT3 Protein - H00349565-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NMNAT3-Antibody-Center-Blocking-peptide - BP14087c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NMNAT3 blocking peptide - GTX88716-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Human NMNAT3 protein - orb244899 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

NMNAT3 Peptide - AC21-1530-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NMNAT3 Peptide - AC21-2540-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NMNAT3 - H00349565-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NMNAT3 - H00349565-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NMNAT3 - H00349565-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NMNAT3 - H00349565-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NMNAT3 Peptide - 46-877P from ProSci Category Peptide

NMNAT3 Peptide - 42-855P from ProSci Category Peptide Species Human

NMNAT3 fusion protein - ag3965 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NMNAT3 fusion protein - ag6936 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human NMNAT3, His-tagged - NMNAT3-639H from Creative Biomart Category Protein Source E.coli.

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