NMNAT3

Gene Symbol NMNAT3
Entrez Gene 349565
Alt Symbol FKSG76, PNAT-3, PNAT3
Species Human
Gene Type protein-coding
Description nicotinamide nucleotide adenylyltransferase 3
Other Description NMN adenylyltransferase 3|NMN/NaMN adenylyltransferase 3|NaMN adenylyltransferase 3|nicotinamide mononucleotide adenylyltransferase 3|nicotinamide-nucleotide adenylyltransferase 3|nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3|nicotinate-nucleotide adenylyltransferase 3|pyridine nucleotide adenylyltransferase 3
Swissprots D3DNF2 B3KVR6 D3DNF3 Q96T66 Q8N4G1
Accessions EAW79022 EAW79023 EAW79024 EAW79025 EAW79026 EAW79027 EAW79028 EAW79029 EAW79030 EAW79031 EAW79032 EAW79033 Q96T66 AA894638 AF345564 AAK52726 AK123208 BAG53878 AK127477 BAG54510 BC034374 AAH34374 BC036218 AAH36218 BX649063 DB454216 DQ890804 ABM81730 DQ893959 ABM84885 XM_006713624 XP_006713687 XM_006713628 XP_006713691 XM_006713629 XP_006713692 XM_011512790 XP_011511092 XM_011512791 XP_011511093 XM_011512792 XP_011511094 XM_011512793 XP_011511095 NM_001200047 NP_001186976 NM_178177 NP_835471
Function Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. {ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
Tissue Specificity Expressed in lung and spleen with lower levels in placenta and kidney. {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
Top Pathways Nicotinate and nicotinamide metabolism

NMNAT-3 CRISPR/Cas9 KO Plasmid (h) - sc-403839 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 HDR Plasmid (h) - sc-403839-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 Double Nickase Plasmid (h) - sc-403839-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 Double Nickase Plasmid (h2) - sc-403839-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 CRISPR Activation Plasmid (h) - sc-403839-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 CRISPR Activation Plasmid (h2) - sc-403839-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 Lentiviral Activation Particles (h) - sc-403839-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 Lentiviral Activation Particles (h2) - sc-403839-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 siRNA (h) - sc-62695 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NMNAT-3 shRNA Plasmid (h) - sc-62695-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NMNAT-3 shRNA (h) Lentiviral Particles - sc-62695-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NMNAT3 RNAi - H00349565-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU084851 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15377 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15377 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06966 from Sigma-Aldrich

Category miRNA

NMNAT3 siRNA (Human) - CRJ7551 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NMNAT-3 CRISPR/Cas9 KO Plasmid (h2) - sc-403839-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NMNAT-3 HDR Plasmid (h2) - sc-403839-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human NMNAT3 (NM_178177.3) - SHH353248 from Creative biogene

Category siRNA
Species Reactivities Human

Human NMNAT3 siRNA - orb278052 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NMNAT3 shRNA Plasmid (Human) - CHJ7551 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NMNAT3 miRNA 3'UTR clone - MiUTR3H-10157 from Creative biogene

Species Reactivities Human
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