NUP50

Gene Symbol NUP50
Entrez Gene 10762
Alt Symbol NPAP60, NPAP60L
Species Human
Gene Type protein-coding
Description nucleoporin 50kDa
Other Description 50 kDa nucleoporin|nuclear pore complex protein Nup50|nuclear pore-associated protein 60L|nucleoporin 50kD|nucleoporin Nup50
Swissprots Q9NPM9 Q9UKX7 O75644 Q9P1K5 Q9NPR6 Q8N6V5 B2RB15 B1AHA4
Accessions EAW73370 EAW73372 EAW73373 Q9UKX7 AF107840 AAD53401 AF116624 AAF71047 AF267865 AAG44734 AK095860 AK304223 BAG65095 AK314454 BAG37062 AL389949 CAB97527 AL389950 CAB97528 AL389951 CAB97529 AL704529 BC016055 AAH16055 BC020260 BC028125 AAH28125 BC039468 BC070133 AAH70133 BI461522 CR456533 CAG30419 CU013133 CAK54564 CU013421 CAK54863 EU832782 ACE87793 GQ129293 ACT64427 XM_005261312 XP_005261369 XM_005261313 XP_005261370 XM_005261314 XP_005261371 XM_006724103 XP_006724166 XM_006724104 XP_006724167 XM_011529833 XP_011528135 NM_007172 NP_009103 NM_153645 NP_705931
Function Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000269|PubMed:20016008}.
Subcellular Location Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase. {ECO:0000250}.
Tissue Specificity Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
Top Pathways RNA transport

NUP50-Over-expression-Lysate - LY12207a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag NUP50 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the NUP50 gene

NUP50 293T Cell Transient Overexpression Lysate(Denatured) - H00010762-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

NUP50 overexpression lysate - LY407000 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

NUP50 overexpression lysate - LY430280 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

NUP50 293 Cell Lysate - 407558 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

NUP50 Overexpression Lysate (Native) - NBL1-13878 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: NUP50 Overexpression Lysate (Adult Normal) [NBL1-13878] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NUP50.

NUP50 Overexpression Lysate (Native) - NBP2-05241 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: NUP50 Overexpression Lysate (Adult Normal) [NBP2-05241] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NUP50.

NUP50 Over-expression Lysate Product - GWB-4998AD from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

NUP50 Overexpression Lysate (Native) - NBP2-10010 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

NUP50 Overexpression Lysate (Denatured) - H00010762-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

NUP50 Overexpression Lysate (Denatured) - H00010762-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human NUP50 Knockdown Stable Cell Line - CSC-DC010743 from Creative biogene

Category Cell Line
Species Human
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