NUP50
| Gene Symbol | NUP50 |
|---|---|
| Entrez Gene | 10762 |
| Alt Symbol | NPAP60, NPAP60L |
| Species | Human |
| Gene Type | protein-coding |
| Description | nucleoporin 50kDa |
| Other Description | 50 kDa nucleoporin|nuclear pore complex protein Nup50|nuclear pore-associated protein 60L|nucleoporin 50kD|nucleoporin Nup50 |
| Swissprots | Q9NPM9 Q9UKX7 O75644 Q9P1K5 Q9NPR6 Q8N6V5 B2RB15 B1AHA4 |
| Accessions | EAW73370 EAW73372 EAW73373 Q9UKX7 AF107840 AAD53401 AF116624 AAF71047 AF267865 AAG44734 AK095860 AK304223 BAG65095 AK314454 BAG37062 AL389949 CAB97527 AL389950 CAB97528 AL389951 CAB97529 AL704529 BC016055 AAH16055 BC020260 BC028125 AAH28125 BC039468 BC070133 AAH70133 BI461522 CR456533 CAG30419 CU013133 CAK54564 CU013421 CAK54863 EU832782 ACE87793 GQ129293 ACT64427 XM_005261312 XP_005261369 XM_005261313 XP_005261370 XM_005261314 XP_005261371 XM_006724103 XP_006724166 XM_006724104 XP_006724167 XM_011529833 XP_011528135 NM_007172 NP_009103 NM_153645 NP_705931 |
| Function | Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000269|PubMed:20016008}. |
| Subcellular Location | Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver. |
| Top Pathways | RNA transport |
Nup50 CRISPR/Cas9 KO Plasmid (h) - sc-406550 from Santa Cruz Biotechnology
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Nup50 HDR Plasmid (h) - sc-406550-HDR from Santa Cruz Biotechnology
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Nup50 Double Nickase Plasmid (h) - sc-406550-NIC from Santa Cruz Biotechnology
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Nup50 Double Nickase Plasmid (h2) - sc-406550-NIC-2 from Santa Cruz Biotechnology
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Nup50 CRISPR Activation Plasmid (h) - sc-406550-ACT from Santa Cruz Biotechnology
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Nup50 CRISPR Activation Plasmid (h2) - sc-406550-ACT-2 from Santa Cruz Biotechnology
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Nup50 Lentiviral Activation Particles (h) - sc-406550-LAC from Santa Cruz Biotechnology
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Nup50 Lentiviral Activation Particles (h2) - sc-406550-LAC-2 from Santa Cruz Biotechnology
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Nup50 siRNA (h) - sc-75979 from Santa Cruz Biotechnology
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Nup50 shRNA Plasmid (h) - sc-75979-SH from Santa Cruz Biotechnology
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Nup50 shRNA (h) Lentiviral Particles - sc-75979-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108761 from Sigma-Aldrich
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MISSION® esiRNA - EHU114251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15630 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15630 from Sigma-Aldrich
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NUP50 siRNA (Human) - CRH7332 from Cohesion Biosciences
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NUP50 RNAi - H00010762-R01 from Novus Biologicals
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NUP50 RNAi - H00010762-R02 from Novus Biologicals
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Nup50 CRISPR/Cas9 KO Plasmid (h2) - sc-406550-KO-2 from Santa Cruz Biotechnology
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Nup50 HDR Plasmid (h2) - sc-406550-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NUP50(NM_153645.2) - SHR017222 from Creative biogene
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shRNA set against Human NUP50(NM_007172.3) - SHR017240 from Creative biogene
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NUP50 shRNA Plasmid (Human) - CHH7332 from Cohesion Biosciences
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NUP50 miRNA 3'UTR clone - MiUTR1H-06995 from Creative biogene
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NUP50 miRNA 3'UTR clone - MiUTR1H-06996 from Creative biogene
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