NUP50

Gene Symbol	NUP50
Entrez Gene	10762
Alt Symbol	NPAP60, NPAP60L
Species	Human
Gene Type	protein-coding
Description	nucleoporin 50kDa
Other Description	50 kDa nucleoporin|nuclear pore complex protein Nup50|nuclear pore-associated protein 60L|nucleoporin 50kD|nucleoporin Nup50
Swissprots	Q9NPM9 Q9UKX7 O75644 Q9P1K5 Q9NPR6 Q8N6V5 B2RB15 B1AHA4
Accessions	EAW73370 EAW73372 EAW73373 Q9UKX7 AF107840 AAD53401 AF116624 AAF71047 AF267865 AAG44734 AK095860 AK304223 BAG65095 AK314454 BAG37062 AL389949 CAB97527 AL389950 CAB97528 AL389951 CAB97529 AL704529 BC016055 AAH16055 BC020260 BC028125 AAH28125 BC039468 BC070133 AAH70133 BI461522 CR456533 CAG30419 CU013133 CAK54564 CU013421 CAK54863 EU832782 ACE87793 GQ129293 ACT64427 XM_005261312 XP_005261369 XM_005261313 XP_005261370 XM_005261314 XP_005261371 XM_006724103 XP_006724166 XM_006724104 XP_006724167 XM_011529833 XP_011528135 NM_007172 NP_009103 NM_153645 NP_705931
Function	Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B. {ECO:0000269|PubMed:20016008}.
Subcellular Location	Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Nucleoplasmic side {ECO:0000250}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis. Associates to the newly formed nuclear membrane during telophase. {ECO:0000250}.
Tissue Specificity	Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nup50 (B-6) - sc-398992 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Nup50 (G-4) - sc-398993 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Nup50 (S-15) - sc-86768 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Nup50 (V-24) - sc-133859 from Santa Cruz Biotechnology Prices $279.00 Sizes 50 µg/0.5 ml Host Rabbit Clonality Polyclonal

Anti-NUP50 antibody - ab4005 from Abcam Prices $380.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-NUP50 antibody - ab85915 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NUP50 antibody - ab129297 from Abcam Prices $407.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-NUP50 antibody - ab135503 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NUP50 antibody - ab89524 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-NUP50 antibody - ab130671 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NUP50 antibody [EPR9525] - ab151567 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9525

Anti-NUP50 antibody [EPR9526] - ab137092 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR9526

Anti-NUP50 antibody - C-terminal - ab151581 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NUP50 Antibody (aa418-468) - LS-C126071 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NUP50 Antibody (clone 247CT10.2.5, AP) - LS-C212513 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 247CT10.2.5

Anti-NUP50 Antibody (clone 247CT10.2.5, APC) - LS-C212514 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 247CT10.2.5

Anti-NUP50 Antibody (clone 247CT10.2.5, Biotin) - LS-C212515 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 247CT10.2.5

Anti-NUP50 Antibody (clone 247CT10.2.5, Azide-free, HRP) - LS-C212516 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 247CT10.2.5

Anti-NUP50 Antibody (clone 247CT10.2.5, FITC) - LS-C212517 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 247CT10.2.5

Anti-NUP50 Antibody (clone 247CT10.2.5, PE) - LS-C212518 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 247CT10.2.5

Anti-NUP50 Antibody (aa224-252, AP) - LS-C216138 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUP50 Antibody (aa224-252, APC) - LS-C216139 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUP50 Antibody (aa224-252, Biotin) - LS-C216140 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NUP50 Antibody - LS-C163073 from LifeSpan Bioscience Prices $295.00 Sizes 100 µl Host Mouse Clonality Monoclonal

Anti-NUP50 Antibody (aa307-356) - LS-C81710 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

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