UCP1

Gene Symbol UCP1
Entrez Gene 7350
Alt Symbol SLC25A7, UCP
Species Human
Gene Type protein-coding
Description uncoupling protein 1 (mitochondrial, proton carrier)
Other Description mitochondrial brown fat uncoupling protein 1|solute carrier family 25 member 7|thermogenin
Swissprots Q13218 Q68G66 Q4KMZ3 P25874
Accessions AAY41026 CAA36214 EAX05095 P25874 BC069556 AAH69556 BC096736 AAH96736 BC098168 AAH98168 BC098258 AAH98258 BC098352 AAH98352 U28480 AAA85271 XM_005263206 XP_005263263 XM_011532228 XP_011530530 NM_021833 NP_068605
Function UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Subcellular Location Mitochondrion inner membrane; Multi-pass membrane protein.
Tissue Specificity Brown adipose tissue. {ECO:0000269|PubMed:3165741}.
Top Pathways Huntington's disease, PPAR signaling pathway

UCP1 (D9D6X) Rabbit mAb - 14670 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9D6X
Western blot analysis of extracts from mouse brown adipose tissue (positive) and mouse prostate (negative) using UCP1 (D9D6X) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

UCP1 (M-17) - sc-6529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UCP1 (C-17) - sc-6528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UCP1/2/3 (H-300) - sc-28766 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
UCP1/2/3 (FL-307): sc-28766. Immunofluorescence staining of normal mouse heart frozen section showing cytoplasmic staining.

Anti-UCP1 antibody - ab23841 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-UCP1 antibody (ab23841) at 1 µg/mlLane 1 : Adult Mouse Brown Adipose Tissue LysateLane 2 : Adult Rat Brown Adipose Tissue LysateLysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-UCP1 antibody - ab155117 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-UCP1 antibody (ab155117) at 1/1000 dilution + Mouse interscapular brown adipose tissue whole cell lysate at 2.5 µg

Anti-UCP1 antibody - ab57687 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Overlay histogram showing HepG2 cells stained with ab57687 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab57687, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was an anti-mouse Alexa Fluor® 488 (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2a [ICIGG2A] (ab91361, 0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HepG2 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-UCP1 antibody - ab125480 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-UCP1 antibody (ab125480) at 1 µg/ml + A549 lysate at 10 µgSecondaryGoat anti-Rabbit IgG HRP

Anti-UCP1 antibody - Carboxyterminal end - ab47991 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-UCP1 antibody - Carboxyterminal end (ab47991) at 1 µg/ml + Human Adipose lysate (35µg protein in RIPA buffer).

Anti-UCP1 / UCP-1 Antibody (C-Terminus) - LS-C10946 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody - LS-C132799 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-UCP1 / UCP-1 Antibody - LS-C87137 from LifeSpan Bioscience

Prices $755.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (aa288-304) - LS-C148917 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (aa179-296) - LS-C296914 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (aa179-296, Biotin) - LS-C298483 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (aa179-296, Biotin) - LS-C298486 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (aa179-296, FITC) - LS-C301845 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (aa179-296, FITC) - LS-C302056 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (Biotin) - LS-C317902 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (HRP) - LS-C317903 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody - LS-C317904 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (FITC) - LS-C318975 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody - LS-C341913 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UCP1 / UCP-1 Antibody (C-Terminus) - LS-C146466 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UCP1 antibody LS-C146466 Western blot of A549 Cell lysate. Antibody concentration 1 ug/ml.

Anti-UCP1 / UCP-1 Antibody (aa77-126) - LS-C146311 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UCP1 antibody LS-C146311 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.
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