| Gene Symbol |
UCP1
|
| Entrez Gene |
7350
|
| Alt Symbol |
SLC25A7, UCP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
uncoupling protein 1 (mitochondrial, proton carrier)
|
| Other Description |
mitochondrial brown fat uncoupling protein 1|solute carrier family 25 member 7|thermogenin
|
| Swissprots |
Q13218 Q68G66 Q4KMZ3 P25874
|
| Accessions |
AAY41026 CAA36214 EAX05095 P25874 BC069556 AAH69556 BC096736 AAH96736 BC098168 AAH98168 BC098258 AAH98258 BC098352 AAH98352 U28480 AAA85271 XM_005263206 XP_005263263 XM_011532228 XP_011530530 NM_021833 NP_068605
|
| Function |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
|
| Subcellular Location |
Mitochondrion inner membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Brown adipose tissue. {ECO:0000269|PubMed:3165741}.
|
| Top Pathways |
Huntington's disease, PPAR signaling pathway
|