| Gene Symbol |
GNRHR
|
| Entrez Gene |
2798
|
| Alt Symbol |
GNRHR1, GRHR, HH7, LHRHR, LRHR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gonadotropin-releasing hormone receptor
|
| Other Description |
gnRH receptor|gnRH-R|gonadotropin-releasing hormone (type 1) receptor 1|leutinizing hormone releasing horomone receptor|leutinizing-releasing hormone receptor|luliberin receptor|type I GnRH receptor
|
| Swissprots |
Q92644 Q14D13 O75793 P30968
|
| Accessions |
AAA63884 AAA63885 AAB71348 CAB17082 CAI72249 EAX05557 EAX05558 P30968 AY392011 AAR92228 BC113546 AAI13547 HQ258385 ADR83139 L03380 AAA35918 L07949 AAA35917 S60587 AAB26287 S77472 AAB33884 Z81148 CAB03541 NM_000406 NP_000397 NM_001012763 NP_001012781
|
| Function |
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Pituitary, ovary, testis, breast and prostate but not in liver and spleen.
|
| Top Pathways |
GnRH signaling pathway, Neuroactive ligand-receptor interaction
|