Gene Symbol | GNRHR |
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Entrez Gene | 2798 |
Alt Symbol | GNRHR1, GRHR, HH7, LHRHR, LRHR |
Species | Human |
Gene Type | protein-coding |
Description | gonadotropin-releasing hormone receptor |
Other Description | gnRH receptor|gnRH-R|gonadotropin-releasing hormone (type 1) receptor 1|leutinizing hormone releasing horomone receptor|leutinizing-releasing hormone receptor|luliberin receptor|type I GnRH receptor |
Swissprots | Q92644 Q14D13 O75793 P30968 |
Accessions | AAA63884 AAA63885 AAB71348 CAB17082 CAI72249 EAX05557 EAX05558 P30968 AY392011 AAR92228 BC113546 AAI13547 HQ258385 ADR83139 L03380 AAA35918 L07949 AAA35917 S60587 AAB26287 S77472 AAB33884 Z81148 CAB03541 NM_000406 NP_000397 NM_001012763 NP_001012781 |
Function | Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Pituitary, ovary, testis, breast and prostate but not in liver and spleen. |
Top Pathways | GnRH signaling pathway, Neuroactive ligand-receptor interaction |
GnRHR CRISPR/Cas9 KO Plasmid (h) - sc-401783 from Santa Cruz Biotechnology
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GnRHR HDR Plasmid (h) - sc-401783-HDR from Santa Cruz Biotechnology
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GnRHR Double Nickase Plasmid (h) - sc-401783-NIC from Santa Cruz Biotechnology
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GnRHR Double Nickase Plasmid (h2) - sc-401783-NIC-2 from Santa Cruz Biotechnology
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GnRHR CRISPR Activation Plasmid (h) - sc-401783-ACT from Santa Cruz Biotechnology
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GnRHR CRISPR Activation Plasmid (h2) - sc-401783-ACT-2 from Santa Cruz Biotechnology
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GnRHR Lentiviral Activation Particles (h) - sc-401783-LAC from Santa Cruz Biotechnology
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GnRHR Lentiviral Activation Particles (h2) - sc-401783-LAC-2 from Santa Cruz Biotechnology
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GnRHR siRNA (h) - sc-40012 from Santa Cruz Biotechnology
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GnRHR shRNA Plasmid (h) - sc-40012-SH from Santa Cruz Biotechnology
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GnRHR shRNA (h) Lentiviral Particles - sc-40012-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU150031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1088 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1088 from Sigma-Aldrich
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GNRHR siRNA (Human) - CRH1868 from Cohesion Biosciences
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GnRHR RNAi - H00002798-R03 from Novus Biologicals
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GnRHR RNAi - H00002798-R04 from Novus Biologicals
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GNRHR - MBS8207488 from MyBioSource
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shRNA set against Human GNRHR (NM_000406.2) - SHH305130 from Creative biogene
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shRNA set against Human GNRHR(NM_000406.2) - SHH093665 from Creative biogene
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shRNA set against Human GNRHR(NM_001012763.1) - SHH093685 from Creative biogene
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shRNA set against Human GNRHR(NM_000406.2) - SHH093707 from Creative biogene
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shRNA set against Human GNRHR(NM_001012763.1) - SHH093723 from Creative biogene
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Human GNRHR siRNA - orb262370 from Biorbyt
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GNRHR shRNA Plasmid (Human) - CHH1868 from Cohesion Biosciences
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