SNW1

Gene Symbol SNW1
Entrez Gene 22938
Alt Symbol Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP
Species Human
Gene Type protein-coding
Description SNW domain containing 1
Other Description SKI interacting protein|SKI-interacting protein|SNW domain-containing protein 1|homolog of Drosophila BX42|nuclear protein SkiP|nuclear receptor coactivator NCoA-62|nuclear receptor coactivator, 62-kD
Swissprots Q5D0D6 Q13483 A8K8A9 Q13573 Q32N03
Accessions AAB48857 AAF01479 AAF23325 EAW81305 EAW81306 EAW81307 EAW81308 Q13573 AF045184 AAC31697 AK292274 BAF84963 AK293619 BAG57078 AK302246 BAG63598 AK316087 BAH14458 AX775981 CAE11690 BC032377 BC040112 AAH40112 BC046105 AAH46105 BC065286 AAH65286 BC105585 AAI05586 BC108902 BC108903 AAI08904 BT020060 AAV38863 BT020061 AAV38864 CR457433 CAG33714 U51432 AAC15912 XM_005267413 XP_005267470 XM_005267414 XP_005267471 NM_012245 NP_036377
Function Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to t
Subcellular Location Nucleus {ECO:0000269|PubMed:12840015}.
Top Pathways Notch signaling pathway, Spliceosome, Viral carcinogenesis, Epstein-Barr virus infection

Skip (D-5) - sc-393856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Skip (D-5): sc-393856. Western blot analysis of Skip expression in HeLa nuclear extract (A) and ES-2 (B) and A-375 (C) whole cell lysates.

Skip (F-10) - sc-393535 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Skip (F-10): sc-393535. Western blot analysis of Skip expression in HeLa nuclear extract (A) and HeLa (B) and A-375 (C) whole cell lysates.

Skip (C-15) - sc-21812 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Skip (C-15): sc-21812. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

Skip (N-17) - sc-21810 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Skip (15) - sc-136546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Skip (15): sc-136546. Western blot analysis of Skip expression in HeLa whole cell lysate.

Skip (H-300) - sc-30139 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Skip (H-300): sc-30139. Immunoperoxidase staining of formalin fixed, paraffin-embedded human esophagus tissue showing nuclear and cytoplasmic staining of surface epithelial cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-NCOA62 antibody [EPR9988(B)] - ab151553 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9988(B)
All lanes : Anti-NCOA62 antibody [EPR9988(B)] (ab151553) at 1/1000 dilutionLane 1 : Raw264.7 cell lysateLane 2 : 293T cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-NCOA62 antibody [EPR9989(B)] - ab167165 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR9989(B)
All lanes : Anti-NCOA62 antibody [EPR9989(B)] (ab167165) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : A431 cell lysateLane 3 : Raw264.7 cell lysateLane 4 : NIH/3T3 cell lysateLane 5 : 293T cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-SNW1 / SKIP Antibody (C-Terminus) IHC-plus™ - LS-B590 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SNW1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B590 concentration 5 ug/ml.

Anti-SNW1 / SKIP Antibody (aa450-500) - LS-C73191 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SNW1 / SKIP Antibody (C-Terminus) - LS-C73192 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SNW1 / SKIP Antibody (aa103-152) - LS-C29711 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SNW1 / SKIP antibody LS-C29711 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-SNW1 / SKIP Antibody (aa450-500) - LS-C287641 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human NCOA62 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-NCOA62 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-SNW1 / SKIP Antibody (aa450-500) - LS-C286442 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse NCOA62 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-NCOA62 used at a dilution of 1:250.

Anti-SNW1 / SKIP Antibody (C-Terminus) - LS-C287646 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse NCOA62 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-NCOA62 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.

SNW1 Antibody - NBP1-88523 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SNW1 Antibody - NBP1-31676 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNW1 Antibody [NBP1-31676] - Sample (30 ug of whole cell lysate) A: Raji 7. 5% SDS PAGE; antibody diluted at 1:10000.

SNW1 Antibody - NB100-2367 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNW1 Antibody [NB100-2367] - Detection of Human and Mouse NCOA62 on HeLa whole cell lysate using NB100-2367. NCOA62 was also immunoprecipitated by rabbit anti-NCOA62 antibody NB100-2368.

SNW1 Antibody - NB100-2368 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNW1 Antibody [NB100-2368] - Detection of Human and Mouse NCOA62 on HeLa whole cell lysate using NB100-2368. NCOA62 was also immunoprecipitated by rabbit anti-NCOA62 antibody NB100-2367.

SNW1 Antibody - NBP1-88524 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNW1 Antibody [NBP1-88524] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

SNW1 Antibody - NBP2-20440 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SNW1 Antibody [NBP2-20440] - Sample (30 ug of whole cell lysate) A: A549 B: HepG2 7. 5% SDS PAGE gel, diluted at 1:1000.

SNW1 Antibody - H00022938-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-SNW1 antibody produced in rabbit - HPA017370 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SNW1: <B>Cat. No. HPA017370</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human esophagus shows strong nuclear membranous positivity in squamous epithelial cells,.

Anti-SNW1 antibody produced in rabbit - HPA002457 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SNW1: <B>Cat. No. HPA002457</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human stomach tissue showing strong nuclear staining of glandular cells.

Anti-SkiP antibody produced in rabbit - SAB3500226 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SkiP: <B>Cat. No. SAB3500226</B>: Immunofluorescence of Ski in human kidney tissue with Ski antibody at 20 μg/mL.
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