SNW1

Gene Symbol	SNW1
Entrez Gene	22938
Alt Symbol	Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP
Species	Human
Gene Type	protein-coding
Description	SNW domain containing 1
Other Description	SKI interacting protein|SKI-interacting protein|SNW domain-containing protein 1|homolog of Drosophila BX42|nuclear protein SkiP|nuclear receptor coactivator NCoA-62|nuclear receptor coactivator, 62-kD
Swissprots	Q5D0D6 Q13483 A8K8A9 Q13573 Q32N03
Accessions	AAB48857 AAF01479 AAF23325 EAW81305 EAW81306 EAW81307 EAW81308 Q13573 AF045184 AAC31697 AK292274 BAF84963 AK293619 BAG57078 AK302246 BAG63598 AK316087 BAH14458 AX775981 CAE11690 BC032377 BC040112 AAH40112 BC046105 AAH46105 BC065286 AAH65286 BC105585 AAI05586 BC108902 BC108903 AAI08904 BT020060 AAV38863 BT020061 AAV38864 CR457433 CAG33714 U51432 AAC15912 XM_005267413 XP_005267470 XM_005267414 XP_005267471 NM_012245 NP_036377
Function	Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to t
Subcellular Location	Nucleus {ECO:0000269|PubMed:12840015}.
Top Pathways	Notch signaling pathway, Spliceosome, Viral carcinogenesis, Epstein-Barr virus infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NCOA62 peptide - ab104464 from Abcam Category Peptide

SNW1 / SKIP Antibody Blocking Peptide - LS-E11289 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNW1 / SKIP Antibody Blocking Peptide - LS-E29931 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human SNW1 Protein - H00022938-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SNW1 Blocking Peptide - NBP1-77304PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

SKIP - H00022938-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SKIP - H00022938-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SKIP Control Peptide - AP30791CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SkiP Peptide - 2261P from ProSci Category Peptide Species Human

SNW1 fusion protein - Ag23106 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET30a Species Human

SNW1 fusion protein - ag16651 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SNW1, His-tagged - SNW1-29295TH from Creative Biomart Category Protein Source E. coli

Recombinant Human SNW domain-containing protein 1(SNW1) - CSB-YP614428HU CSB-EP614428HU CSB-BP614428HU CSB-MP614428HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SNW1 Recombinant Protein Antigen - NBP1-88524PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SNW1 Recombinant Protein Antigen - NBP1-88523PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SNW1-Blocking-Peptide-C-Term - BP21848b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNW1 Peptide, Human - M34GP14840H from Creative Peptides Category Peptide Source Synthetic. Species Human

SNW domain-containing protein 1 (SNW1), Recombinant Protein - MBS1417297 from MyBioSource Category Protein Prices $1,325.00, $1,325.00, $1,545.00, $1,545.00, $2,195.00, $2,195.00, $2,660.00, $2,660.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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